1. Etiology
Primary intestinal bile acid stones may be due to excessive gastric acid secretion, which lowers the pH of the proximal jejunum, or due to excessive bacterial proliferation in the intestinal loop, causing the jejunum pH to drop, while decomposing bile salts into bile acids. Bile acids are not soluble in water in the jejunum with a lower pH, forming bile acid crystals. Bile acid crystals can serve as the core of stones, and together with certain insoluble or indigestible inorganic salts, food, or foreign bodies, they form special coagulants or hard lumps in the gastrointestinal tract, becoming intestinal stones. The enlargement of stones can block the small intestine, leading to intestinal obstruction caused by intestinal stones.
Second, pathogenesis
According to the mixed components of intestinal stones, the intestinal stones causing obstruction can be divided into 3 types:
1, True intestinal stones:Generally, it is composed of a core consisting of intestinal mucosal epithelium, small fecal stones, fruit kernels, and other foreign bodies, which forms a stone after the deposition of inorganic salts.
2, Drug-induced intestinal stones:It is an insoluble hard mass formed in the intestine after long-term oral intake of drugs containing calcium, phosphorus, and magnesium.
3, Mixed intestinal stones (plant hair-like stones):Formed by eating certain fruits, vegetables, or swallowing hair, especially eating unripe fruits is more likely to form.
Among the stones that cause intestinal obstruction, plant hair-like stones are more common. Among them, the plant stones formed by persimmons are the most common. Unripe persimmon juice and ripe persimmon skin contain tannic acid, which, when in contact with gastric acid, forms a gelatinous polymer and precipitates, and then continuously adsorbs plant fibers to form lumps. After the inorganic salts such as calcium, phosphorus, and magnesium are deposited, they form intestinal stones. The more persimmons eaten, the easier it is to form stones. Hair-like stones are often seen in people with mental disorders who have eaten their own or others' hair, leaf fibers, woolen clothing, etc. A large amount of hair can be tangled with gastrointestinal peristalsis to form a ball, thus forming a solid and isolated mass. There are also reports that a part of the gastrointestinal anastomosis line has fallen off and formed a core for the formation of stones leading to intestinal obstruction. People with a history of gastric surgery, such as subtotal gastric resection with Billroth II anastomosis, vagotomy, pyloroplasty, etc., are more prone to form stones. Michael reported that among 113 cases of gastrointestinal stones, 106 had undergone gastric surgery. The reason is that after gastric surgery, the gastric peristalsis is slow, and the emptying is delayed, which makes the contact time between the gastric contents and gastric acid longer, and it is easy to form gastric stones, especially after eating persimmons. After gastric surgery, especially after Billroth II anastomosis, due to the larger anastomotic mouth, the gastric stones formed in the stomach are more likely to enter the small intestine and cause obstruction. It is also easy to form intestinal stones at the site of intestinal diverticula and the proximal part of intestinal stricture.