1Skin damage:Purple-red, painful inflammatory subcutaneous nodules can appear at any part of both lower legs, but they are more common in the skin above the medial malleolus of the lower leg, the diameter of the nodules ranges from a few millimeters to several centimeters, some larger skin lesions may have swelling around them, the subcutaneous nodules are adherent to the skin above them, but they can be moved when touched, mild cases may have only one attack, the nodules do not break, and2,3Within a week, it will sink, and there may be slight pigmented spots left, this type of skin damage usually accompanied by abdominal pain that occurs with recurrent chronic pancreatitis, but some patients may have fever and polyarthritis or arthritis, severe patients, in addition to the face, other fat tissues outside the skin of the whole body are often involved, some large nodules are palpable, resembling abscesses, palpable with fluctuation, if the nodules break spontaneously, a white cheesy or oily sticky substance may exude, several nodules can merge into larger fluctuant plaques, through several openings between the nodules can communicate with each other, when the nodules occur, they are often accompanied by persistent high fever, malaise, fatigue, poor appetite, and insomnia, and other systemic symptoms.
2Pancreatic lesions:Patients with pancreatitis associated with pancreatic cancer may have varying degrees of abdominal pain, mostly dull pain, severe cases may present with colic or knife-cutting pain, often sudden onset, usually after meals2Within 24 hours, the pain gradually worsens, mostly located in the upper middle abdomen, the pain often radiates to the lumbar and back, a few may radiate to the shoulder, generally lasting3～5Within a day, most patients with acute pancreatitis may experience nausea, vomiting, and in severe cases, bile may be mixed in the vomit. A few patients may have jaundice, which is often due to biliary inflammation or pancreatitis edema compressing the common bile duct. Sometimes shock may occur, and the patient's skin may become pale, cold sweat, pulse thin, and blood pressure drop. Physical examination may reveal reduced respiratory sounds and moist rales in the lower lungs, abdominal distension, abdominal muscle tension, but no rigid abdomen, epigastric tenderness and rebound pain, decreased bowel sounds, and sometimes hypocalcemia may occur. Tetany, more than half of the patients have liver enlargement, some patients may have superficial thrombophlebitis, in chronic pancreatitis, in addition to abdominal pain, there are also symptoms such as nausea, vomiting, loss of appetite, abdominal distension, and steatorrhea.
