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Postcholecystectomy syndrome

  Postcholecystectomy syndrome (PCS) refers to the general term for abdominal symptoms such as abdominal pain and dyspepsia that occur after cholecystectomy. Among patients who have undergone cholecystectomy, 20-40% continue to experience the original symptoms postoperatively, or they may recur or develop new symptoms 2-3 months after the operation. In fact, it is not a true syndrome; the causes of these symptoms are numerous and the clinical manifestations vary, including many biliary and non-biliary diseases, many of which are unrelated to the cholecystectomy itself. This 'unexplained pain' is not well treated with internal medicine.

 

Table of Contents

1. What are the causes of post-cholecystectomy syndrome
2. What complications can post-cholecystectomy syndrome lead to
3. What are the typical symptoms of post-cholecystectomy syndrome
4. How to prevent post-cholecystectomy syndrome
5. What laboratory tests need to be done for post-cholecystectomy syndrome
6. Dietary taboos for patients with post-cholecystectomy syndrome
7. Conventional methods of Western medicine for the treatment of post-cholecystectomy syndrome

1. What are the causes of post-cholecystectomy syndrome

  Post-cholecystectomy syndrome (PCS) can be divided into two types, the first type is biliary and pancreatic diseases that can be clearly identified at the current level of diagnosis; the second type is the 'true' PCS that cannot be identified at present. The causes of post-cholecystectomy syndrome are:
  1, symptoms continue before surgery
  (1) Misdiagnosis or incomplete diagnosis: incorrect standards of gallbladder abnormalities, aerophagia, irritable bowel syndrome, hiatus hernia, duodenal ulcer, coronary artery disease, intercostal neuritis.
  (2) Recurrent gallstones.
  (3) Intrahepatic stones.
  (4) Lesions of adjacent organs: pancreatitis, Oddi sphincter stenosis, stricturing cholangitis or cholecystitis, liver disease (hepatocirrhosis), tumors ignored.
  2, symptoms caused by cholecystectomy itself
  (1) Surgical operation failure: left behind intrahepatic or extrahepatic bile duct stones, or tumors ignored.
  (2) Surgical operation errors: injury to the bile duct. Immediate: hemorrhage, choleperitoneum, abscess, fistula; delayed: stricture, residual cystic duct.
  (3) Postoperative adhesion.
  (4) Physiological disorder: removal of the functional gallbladder, dysfunction of the Oddi sphincter.
  3, other spiritual factors, etc.
  Generally, 'post-cholecystectomy syndrome' is limited to the anatomical and physiological disorders of extrahepatic bile ducts that continue to exist or occur recently after biliary tract surgery. 90% to 95% of patients with cholecystitis can be cured after cholecystectomy, but symptoms can continue to exist or recur in a few patients, and some patients may develop new symptoms that are inconsistent with the main complaints before surgery, indicating that these situations are not all due to cholecystectomy.
  The vast majority of PCS are due to preoperative misdiagnosis, that is, the symptoms are not caused by biliary tract diseases, and in some cases, symptoms caused by diseases of adjacent organs (bile duct, liver, pancreas, duodenum) can also be similar to those before surgery, of course, the symptoms after surgery cannot be relieved.
  The occurrence of stones after cholecystectomy is mostly due to inadequate exploration during surgery, with small stones that fell into the common bile duct from the cystic duct not being discovered. If intraoperative contrast imaging and intraoperative cholangioscopy are performed, the incidence of residual stones can be significantly reduced; another situation is that stones are formed due to metabolic disorder after cholecystectomy when there were no stones originally; another situation is due to the inattention of surgery or unavoidable complications of the surgery itself.
  Biliary duct stenosis is often due to blunt injury to the bile duct during surgery that was not detected, and symptoms are discovered only after performing PTC or ERCP. The hardening, stenosis, and pancreatitis of the duodenal papilla, as well as the hardening and stenosis of the pancreatic duct and the onset of pancreatitis, may be due to the forced passage of a metal probe through the papilla during the examination of the duodenum and bile duct, causing injury to the Oddi sphincter. The injury can also lead to cholesterol deposition on the terminal bile duct mucosa, resulting in chronic inflammation.
  The incidence of PCS is not significantly related to the following factors: the gallbladder function shown in oral cholecystography; the size and number of gallstones in the gallbladder; cholecystitis without stones. In recent years, due to more accurate and comprehensive diagnosis than before, the diagnosis of these diseases can be made clear.
  The second type of PCS is numerous, and the exact cause is not yet clear. Recent studies have shown that the biliary wall of PCS patients is particularly sensitive to changes in pressure. As soon as 1-2 ml of normal saline is injected into the common bile duct, the bile duct pressure increases rapidly and severe pain occurs. In patients with bile reflux before cholecystectomy, the postoperative reflux may worsen, which may be related to dysfunction of the pyloric sphincter. In addition, the persistent pain of PCS may be related to psychological factors, and sometimes it should also be considered that intestinal adhesions or cholecystectomy bed scars may be possible.

 

2. What complications can postcholecystectomy syndrome easily lead to?

  Complications of postcholecystectomy syndrome (PCS):
  1. Pulmonary infection: Due to the patient's long-term bed rest, poor diet, and suffering from illness, the immune system is weakened, making it easy to develop pulmonary infections. Secondly, diseases accompanying cholecystectomy, such as peptic ulcer disease, chronic pancreatitis, and chronic hepatitis, may form infection foci;
  2. Jaundice: It is related to postoperative bile duct stenosis, as well as residual stones and recurrent stones, which cause poor bile drainage and lead to jaundice;
  3. Biliary fistula: It may form due to bile duct injury or loose ligation after surgery, leading to bile leakage and an increased risk of cholecystitis;
  4. Postoperative intra-abdominal hemorrhage.

3. What are the typical symptoms of postcholecystectomy syndrome?

  Half of the patients with postcholecystectomy syndrome (PCS) experience abdominal pain or 'dyspepsia' (fullness in the upper abdomen or upper right quadrant, abdominal rumbling, nausea, vomiting, constipation, intolerance to fats, or diarrhea, etc.) within a few weeks after surgery. The other half of the patients develop symptoms several months or years after surgery. These symptoms are non-specific and vary depending on the underlying cause, but often include pain in the upper right quadrant or upper abdomen, which is more common after meals and presents as sharp pain. Other symptoms may include heartburn, belching, vomiting, and intolerance to fatty foods. A few patients may have severe cholecystitis or pancreatitis, with severe pain that may be accompanied by fever, jaundice, or vomiting. Compared to patients with mild or no symptoms, these patients are often easier to diagnose. Physical examination, in addition to detecting obvious jaundice, usually does not have special value.

4. How to prevent cholecystectomy syndrome?

  The main preventive measures for cholecystectomy syndrome (PCS) are mainly for the post-cholecystectomy care, as follows:
  1. The cholecystectomy performed due to cholecystitis, cholelithiasis, or gallbladder and pancreatic lesions, although the wound has healed and the patient has been discharged, the trauma caused by the surgery, as well as the temporary imbalance of digestive tract function caused by the absence of the conditions for bile storage and concentration, all need a certain amount of time to repair and compensate. Therefore, a certain period of treatment and care is still needed.
  2. Nursing points: when there are liver and pancreatic lesions, they should be treated simultaneously. Life and rest should be regular.
  3. Diet should be regular and moderate, do not overeat.
  4. Pain at the incision site can be relieved by hot compress.
  5. Keep the bowels smooth and easy.
  6. Abdominal adhesion symptoms may occur after surgery. It is usually pain deep in the incision, without fever, vomiting, or soft abdomen, and it relieves with anal exhaust or defecation.
  7. If the patient has abdominal pain, fever, and elevated white blood cells, it should be suspected of cholecystitis, and the patient should be sent to the hospital for treatment at this time.
  8. Diarrhea, it is recommended to go to the hospital to check the routine of feces. The main function of the gallbladder is to secrete bile, decompose fat components into fat micelles, and aid in digestion. Due to improper diet, excessive intake of fat components, it is easy to cause indigestion and diarrhea.

 

5. What laboratory tests should be done for cholecystectomy syndrome?

  Since the process of seeking the cause of cholecystectomy syndrome (PCS) involves many differential diagnoses of various diseases, the choice of various examinations should be based on the patient's medical history, clinical manifestations, and possible etiology. There is no unified pattern, and the results of general laboratory examinations are usually normal. Elevated bilirubin, alkaline phosphatase, amylase, or transaminase are often seen in biliary tree lesions.
  Special examinations include various bile duct imaging, electrocardiogram, X-ray chest film, ultrasound examination, CT scan, endoscopic examination, gastrointestinal barium meal, and even magnetic resonance imaging.
  1. Biochemical examination:White blood cell count, blood urine amylase, liver function, alanine aminotransferase, gamma-glutamyl transpeptidase, and other biochemical tests are very helpful for the diagnosis of bile duct obstruction.
  2. Intrahepatic bile ductography:The biliary tract imaging within the liver is poor, and the extrahepatic bile ducts are also not clear, and the diagnosis is of little value due to the great influence of liver function.
  3. B-ultrasound:It can be found that there are bile duct dilatation, gallstones, bile duct tumors, pancreatitis, etc., which is simple, rapid, and has certain diagnostic value, but with limitations, and cannot show the full view of the biliary system and all symptoms.
  4, Upper gastrointestinal contrast study:It is very helpful in diagnosing hiatus hernia, ulcer disease, duodenal diverticula, etc.
  5, Liver and gallbladder CT scan:Diagnose liver tumors, intrahepatic and extrahepatic bile duct dilatation, cholelithiasis, chronic pancreatitis, etc.
  6, Technetium-99m Tc-HDA liver and gallbladder scintigraphy:Observe the dilation of intrahepatic and extrahepatic bile ducts, cholelithiasis, liver lesions, and gallbladder function, which is simple, non-invasive, and suitable for patients with jaundice.
  7, Endoscopy examination:Including esophagogastroduodenoscopy, gastroscopy, duodenoscopy, etc.
  8, PTC:This direct biliary tract contrast method is suitable for the differentiation and localization of severe jaundice and biliary tract lesions.
  9, Morphine:Neostigmine stimulation test, the method is: inject 10mg morphine and 1mg neostigmine intramuscularly into the patient, and draw blood to measure serum amylase and lipoma before injection, 1 hour, 2 hours, and 4 hours after injection. Abdominal pain in the upper abdomen after injection, and serum enzymes higher than three times the normal value are considered positive.

6. Dietary taboos for patients with post-cholecystectomy syndrome:

  Patients with post-cholecystectomy syndrome should pay attention to health preservation in their diet, which can greatly improve the disease. The specific points are as follows:

  First, the dietary recipe for post-cholecystectomy syndrome (PCS):
  1, Yam and Jujube Porridge: 150g yam, 9 jujubes, 100g rice. Wash the yam, peel, and cut into small pieces; wash and prepare the jujubes and rice. Add an appropriate amount of water to the pot, cook the jujubes and rice into porridge, and when it is five-sixths done, add the yam pieces and continue to cook until the porridge is done. Take 1-2 servings a day, and it can be eaten long-term. Yam has the effects of strengthening the spleen and benefiting the lung, nourishing the kidney and consolidating essence. Jujube has the effects of reinforcing the middle-jiao and benefiting Qi, nourishing the stomach and strengthening the spleen, and nourishing the blood and calming the mind. It is mainly used for dyspepsia due to weakness of the spleen and stomach, bloating and abdominal pain after gallbladder surgery.
  2, Taro Shredded Pork Porridge: 100g fresh taro, 60g lean pork, 100g corn flour. Peel and wash the taro, cut into small pieces; shred the lean pork and set aside. Add an appropriate amount of water to the pot, bring to a boil, sprinkle in the corn flour while stirring to prevent sticking, and then add the shredded pork to cook porridge. When it is five-sixths done, add the taro pieces and continue to cook until the porridge is done. Take two servings a day, and it can be eaten long-term. Taro has a neutral nature, sweet and spicy taste, with the effects of regulating the middle-jiao and benefiting Qi, resolving phlegm and harmonizing the stomach, and softening hardness and dispersing masses. Pork has the effects of nourishing the kidney Yin, nourishing the liver blood, and moistening the skin. Corn is rich in nutrition and has the effects of regulating the middle-jiao and benefiting the brain. It is mainly used for bloating and dyspepsia after gallbladder surgery.
  3, Carp Astragalus Porridge: 250g carp (sliced), 30g fried Astragalus, 20g Sichuan pepper, 250g glutinous rice. First, boil an appropriate amount of water with Sichuan pepper, Astragalus, and ginger to make a decoction, then wash the glutinous rice and add it to the pot. Add the decoction, carp, sugar, scallion whites, and an appropriate amount of water, and cook over high heat until the carp is tender. Remove the carp and drink the porridge. It warms the middle-jiao, disperses cold, and strengthens the spleen and benefits the gallbladder. It is mainly used for abdominal pain, bloating, anorexia, and loose stools after gallbladder surgery.
  4, Job's Tears Chicken Gold Porridge: 50g Job's Tears, 5g chicken gizzard. Add an appropriate amount of water, cook together to make porridge for consumption. It helps in digestion and relieves stomachache, mainly for dyspepsia after gallbladder surgery.
  5. Broad Bean and Fungus Porridge: 100 grams (50 grams for dried products) of fresh white broad bean, 10-15 grams of fungus, 140 grams of glutinous rice, and appropriate amount of brown sugar. The white broad bean is cleaned (for dried products, it needs to be soaked in warm water overnight), and cooked with glutinous rice in a pot, with appropriate amount of water added. It is first brought to a boil with high heat, then changed to low heat to cook porridge until the rice is soft, and then add brown sugar to taste. It can be taken warm for breakfast and dinner. It strengthens the spleen, promotes bile excretion, and nourishes the blood and Qi. Indicated for post-gallbladder surgery poor digestion, abdominal distension, and diarrhea.
  6. Pork Spleen and Stomach Porridge: 100 grams (2 liang) of pork spleen and stomach, 200 grams (4 liang) of rice, a little oil and salt. The pork spleen and stomach are cleaned and cut into small pieces, placed in cleaned rice, and cooked into porridge as usual, and then seasoned with salt when cooked. It can be eaten warm for breakfast and dinner. It strengthens the spleen and stomach, promotes bile excretion, and digests food. Indicated for post-gallbladder surgery weakness, poor digestion, and abdominal distension.
  7. Rehmannia and Longan Chicken: 200 grams (4 liang) of raw rehmannia, 500-750 grams of hen, 30 grams (0.6 liang) of longan meat, 15 grams (0.3 liang) of red dates, 150 grams (3 liang) of malt sugar, 100 grams (2 liang) of sugar, and appropriate amount of chicken soup. After the hen is cleaned of its intestines and washed, it is cut from the neck bone to the tail, the claws are chopped off, and the wing tips are cut off, and then it is briefly scalded in boiling water. The raw rehmannia is cleaned and cut into particles about 0.5 cm square, and the longan meat is torn into pieces and mixed evenly with the rehmannia. Then, it is mixed with malt sugar and stuffed into the hen's belly. The hen is placed belly down in a soup pot, the seeds of the red dates are removed and placed in the soup pot, and then chicken soup is poured in, sealed, and steamed for about 2-3 hours. After the chicken is tender, add sugar to taste. It can be eaten with meals, twice a day. It tonifies the body, benefits the Qi and blood. Indicated for post-gallbladder surgery malnutrition or abdominal distension (diabetics should avoid eating).
  Two, suitable foods for gallbladder resection syndrome
  1. Pay attention to vitamin intake, especially the supplementation of fat-soluble vitamins A, D, E, and K. Vitamin K is effective in controlling bleeding caused by certain types of jaundice.
  2. Adequate protein is beneficial for repairing liver cell damage caused by cholecystitis and gallstones. Therefore, it is advisable to choose low-fat high-quality protein diets mainly containing fish, shrimp, poultry, tofu, and less-oily bean products.
  3. It is beneficial to choose coarse grains more often. Eating foods high in fiber, including corn, millet, sweet potatoes, oats, and buckwheat, can promote bile excretion.
  4. Vegetables and fruits for health. Vegetables and fruits are rich in vitamins, minerals, and dietary fiber, which can reduce cholesterol formation, reduce the absorption of fat and sugar, thereby improving the patient's metabolic disorder and reducing blood lipids and blood sugar levels. The daily intake of vegetables should be more than 500 grams, and at least 2 types of fruit.
  Three, dietary considerations at different stages after surgery
  1. After surgery, due to the stimulation of the gastrointestinal tract, peristalsis decreases, liver function is suppressed, bile secretion decreases, which will affect the function of the entire digestive system. Therefore, for the first 1 to 2 days after surgery, it is necessary to strictly fast and use intravenous drip to supplement various nutrients. From the third day on, the patient can be given liquid food according to the situation, such as congee, soy milk, lotus root starch, fruit juice, and then gradually change to low-fat milk with sweet bread, rice porridge, tofu soup, date paste rice porridge, and various kinds of noodles.
  2. In the first month after surgery, the intake of fatty foods should be reduced, and high-fat and fried foods should be avoided. Some people think that after the 'lesion' is removed, they can change their past low-fat diet, which is wrong. After cholecystectomy, the function of regulating bile into the intestines is lost, and the ability to digest fat is correspondingly weakened. Especially when a large amount of fatty food needs to be digested in a short period of time, it is beyond one's capability, which can cause bloating, diarrhea, and poor digestion. Reducing fat intake mainly refers to not eating or eating as little as possible of fatty meat, animal internal organs, yolks, and fried foods, and it is also not advisable to eat various high-fat and high-calorie 'fast food'. Cooking should use as little animal oil as possible, and vegetable oil can be used in moderation. The main cooking methods should be steaming, stewing, and cold dishes, and less stir-fried dishes should be eaten, especially spicy and刺激性 foods should be avoided, do not drink alcohol, which can reduce the adverse stimulation to the bile duct.
  3. Gradually strengthen nutrition. After one month of cholecystectomy, the diet should also pursue lightness, and necessary nutritional supplements should be strengthened to help the patient recover sooner. After several weeks of adaptation and compensation, the bile duct connecting the liver and the small intestine gradually extends and expands, replacing the function of storing bile in the gallbladder. If there is no abnormality in the digestive function, ordinary diet can be consumed. Protein intake can be appropriately increased, and foods with high-quality protein should be eaten. Some lean meat, aquatic products, and legume foods should be eaten every day, and it is better if a glass of milk can be drunk. If one is not accustomed to eating milk or fish, more soy products and mushrooms can be eaten to make up for the deficiency of animal protein. After cholecystectomy, it is not advisable to consume excessive fat and cholesterol, but it is not necessary to restrict fat excessively, because a certain amount of fat in the intestines is necessary to stimulate bile secretion, expand the bile duct, and maintain the smooth flow of bile ducts. In addition, eating more high-fiber and vitamin-rich foods is also very beneficial to the patient's postoperative recovery.
  4. Increase the frequency of meals appropriately. It should be noted that each meal should not be too heavy, especially within 3 to 6 months after surgery, it is better to have 4 meals a day, and eating less and more often can reduce the burden on the digestive system and is conducive to postoperative recovery. It is best to eat a little vinegar every day, as vinegar can enhance the digestive ability of the stomach and can also regulate the acid-base balance in the intestines, which is conducive to the function of bile and promotes the digestion of fatty foods. Drinking tea frequently, eating more fresh fruits and vegetables also helps in the digestion and absorption of food.
  Four. Foods to avoid after cholecystectomy syndrome
  1. Based on the symptoms and the degree of tolerance to fat, excessive fat intake should be avoided, and it is advocated to use vegetable oil for cooking.
  2. On the basis of meeting the patient's needs, the total caloric intake should not be too high. Obese and overweight patients should lose weight to reach the ideal weight. Caloric intake should be provided according to the principles of low-calorie diet.
  3. Limit the intake of cholesterol. The daily intake of cholesterol should be less than 300 milligrams, and animal fats and foods high in cholesterol, such as internal organs and fish roe, yolks, etc., should be restricted. Fish, lean meat, and egg whites can be chosen instead.
  4、忌用刺激性或产气食品,如萝卜、洋葱等,禁烟、酒。

4, Avoid spicy or gas-producing foods, such as radishes, onions, etc., and quit smoking and drinking.. 7

  Conventional methods for Western medicine treatment of post-cholecystectomy syndrome
  Western medicine treatment for post-cholecystectomy syndrome (PCS):
  Secondly, Surgical Therapy
  Firstly, Non-surgical Therapy
  (1) Bile duct stones with diameter (2) Biliary infection without obvious bile duct obstruction.
  (3) Acute or chronic cholecystitis, pancreatitis.
  (4) Biliary ascariasis.
  (5) Biliary dysfunction.
  (6) Diseases outside the biliary tract, such as hiatal hernia, peptic ulcer, chronic pancreatitis, etc.
  2. Treatment Methods
  (1) General therapy: Including diet therapy, infusion, correction of water, electrolyte and acid-base balance disorders.
  (2) Puncture: Used for pain relief and regulation of biliary tract function.
  (3) Others: Antibiotics, antispasmodic analgesics, antacids, H2-receptor blockers, etc.
  Secondly, Surgical Therapy
  1. Indications
  (1) For patients with recurrent large bile duct stones, intrahepatic bile duct stones, ampulla impaction stones, and bile duct stenosis with bile duct stones.
  (2) For patients with recurrent biliary tract infections due to bile duct stenosis, obstructive suppurative cholangitis.
  (3) For patients with Oddi's sphincter stenosis, chronic pancreatitis with ampulla or pancreatic duct obstruction.
  (4) For patients with a long remaining cystic duct, forming a small inflamed gallbladder.
  (5) For diseases outside the gallbladder that are difficult to cure with medication, such as hiatal hernia and ulcer disease.
  2. Surgical Methods: Determine the surgical method according to the condition of the lesion.
  (1) For patients with a long remaining gallbladder or cystic duct, cholecystectomy or cystic duct resection should be performed.
  (2) For patients with Oddi's sphincter stenosis, sphincterotomy and reconstruction can be performed.
  (4) For patients with bile duct stenosis, bile duct reconstruction can be performed, or bile duct-enteric reconstruction can be performed. Such as choledochojejunal anastomosis, bile duct jejunum Roux-y anastomosis, Longmire surgery, etc.
  (5) For diseases outside the gallbladder with severe symptoms, such as hiatal hernia and ulcer disease, appropriate medication or surgical treatment should also be given.

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