The main causes of milk aspiration pneumonia include the following points:
1. Swallowing disorders:Infants have immature swallowing reflexes and uncoordinated swallowing movements, making them prone to milk aspiration. Brain injury or cranial nerve lesions can also cause delayed or incomplete swallowing reflexes. The emptying time of milk in the pharynx is prolonged, and sometimes due to uncoordinated neuromuscular activity in the pharynx, part of the milk enters the esophagus during swallowing, part flows out through the nasal cavity, and part is inhaled into the respiratory tract, causing pneumonia.
2. Esophageal malformation:When the esophagus is atresia, milk cannot enter the stomach through the esophagus and stays in the pharynx, along with saliva, and is inhaled into the lungs. If there is only a tracheoesophageal fistula, milk can directly enter the lungs through the fistula. However, sometimes the fistula is very small and not easy to find.
3. Incomplete esophageal function:Milk enters the esophagus and then refluxes to the pharynx before being inhaled. For example, infants with relaxed esophageal sphincters are prone to aspiration after vomiting, and sometimes reflux can also be caused by esophageal neuromuscular coordination.
4. Severe cleft palate, hare lip cleft:Generally, it does not affect swallowing, but severe defects may cause difficulty in suckling, which can lead to aspiration.
After milk is aspirated into the alveoli, the lung tissue shows an inflammatory reaction, with neutrophils, phagocytes, and red blood cells exuding a few hours later, thickening of the alveolar wall, and obvious interstitial inflammation. After several weeks, fibrosis appears, and if aspiration occurs repeatedly, it can present as chronic interstitial pneumonia.