Syndrome of ovarian dysfunction

　　The etiology of the syndrome of ovarian dysfunction is unknown, and it may be due to genetic regulatory disorders in the blood vessels of the diencephalon and pituitary, causing autonomic dysfunction in various parts of the brain-diencephalon system.

　　The nerves of the ovary come from the ovarian ganglion and the sympathetic nerve chain through the uterovaginal ganglion, with nerve fibers distributed on blood vessels and smooth muscles. Norepinephrine is the main neurotransmitter. The nerves entering the ovary from the ovarian plexus are mostly ultrafine fibers, accompanying blood vessels into the ovarian stroma, with abundant nerve distribution around the stroma and blood vessels. Studies have found that nerve fibers are present in the secretory cells of the ovarian stroma, the granulosa cell layer of the follicle, the cytoplasm of the oocyte, and the corpus luteum formed, so recently, some people have proposed the hypothesis that follicles and their secretory cells can directly accept neural influences. Recently, some people have used fluorescence histochemical methods to show a large number of adrenergic nerve distributions in the ovary, spreading into terminal networks in the ovarian stroma, and most of these nerve fibers are non-vascularly distributed in the ovarian stroma, with others distributed on the endometrium of mature follicles. These nerve fibers have the function of inhibiting the secretion activity of the ovarian stromal tissue, affecting follicular atresia, follicular maturation, and the secretion of sex hormones, leading to dysfunction of the hypothalamus-pituitary-ovary axis (H-P-0 axis) and the occurrence of abnormal ovarian function.

      Concomitant osteoporosis and changes similar to senile vaginal inflammation, causing difficulty and pain during sexual intercourse. The syndrome of absent ovarian function not only has a negative impact on the appearance, skin, and body of women who love beauty but also leads to infertility, decreased sexual function, and menopausal complications. Some complications similar to menopause make people fear an early onset of aging.

　　In addition to gynecological manifestations, the syndrome of abnormal ovarian function also has systemic symptoms.

　　1. The manifestations of constitutional vascular instability include cold hands and feet, cyanosis of the extremities, erythema, marble-like skin, abnormal sensation in the limbs, easy frostbite, dizziness, weakness, habitual headache, vascular neurotic edema, and excessive sweating.

　　2. The manifestations of incomplete ovarian function include amenorrhea, menorrhagia, irregular menstruation, early onset of menstruation, increased leukorrhea, incomplete development of the reproductive organs.

　　3. Chronic constipation, gastrointestinal dysfunction caused by endocrine abnormalities, loss of consciousness, and restlessness.

      1. In terms of spirit, it is important to uplift one's spirit, try to maintain a cheerful mood, do not put too much pressure on oneself, and women should treat the onset of menopause and old age with a positive attitude, eliminate unnecessary worries and fears, and take positive and effective measures to deal with any discomforts. It is also important to be good at receiving sympathy, comfort, and encouragement from family members.

2. In terms of physical exercise, persistence in exercise and strengthening physical fitness is the most important way for middle-aged women to maintain vigorous vitality. A strong physique can maintain the healthy function and coordination of all organs and systems in the body, thereby naturally delaying the decline of ovarian function due to the destruction of the nervous and endocrine systems.

3. In terms of diet, attention should be paid to dietary adjustment to ensure the intake of sufficient nutrients, which can help women obtain the necessary nutrition to maintain the healthy function of the reproductive system. Women can consume more high-quality proteins, B vitamins, folic acid, iron, calcium, and other nutrients such as eggs, pork liver, beans and their products, fresh vegetables, mushrooms, black fungus, kelp, seaweed, and fish. At the same time, it is necessary to maintain a light diet and avoid overly greasy, salty, or sweet foods. Regular meals and avoiding overeating are important.

4. Sexual intimacy, a happy and fulfilling conjugal sexual life, has great health benefits for women. Sex promotes the secretion of female hormones, promotes breast development, and can alleviate dysmenorrhea. Sexual activity is beneficial for eliminating the seminal plasma, which has a bactericidal effect similar to penicillin, and has a suppressive effect on diseases such as vaginitis, cervicitis, endometritis, and salpingitis.

5. Pay attention to the menstrual period. Ovarian failure has symptoms, and most of the time there is a process of menstrual reduction - oligomenorrhea - amenorrhea before the onset. Therefore, it is important to pay attention to changes in menstruation.

5. Women should not take hormone drugs or health products randomly. Improper hormone supplementation and poor health care can lead to excessive stimulation of the ovaries, causing significant adverse effects, leading to the opposite of the intended result, and exacerbating amenorrhea.

Laparoscopy, estrogen, vaginal secretion examination, colposcopy examination

Hormonal level tests, secretion tests.

Colposcopy, laparoscopy, and histopathological examination.

First, diet

1. Dietetic recipes for women with absent ovarian function:

·Take 30 grams of bamboo shoots and wolfberry fruits, 100 grams of lean pork, pork oil, salt, MSG, soy sauce, and cornstarch. Heat the pork oil in a wok, add the pork slices and bamboo shoots, and stir-fry until cooked. Add the other seasonings and it is ready. Take it once a day. It is suitable for those with early ovarian failure who have symptoms such as dizziness, irritability, heavy menstrual bleeding, dark complexion, and hot palms and soles.

·Boil 30 grams of Job's tears, red beans, and rice, and eat it as porridge three times a day. It is suitable for those with early ovarian failure who have symptoms such as edema, loose skin, and joint pain.

·Decoct 10 red dates, 30 grams of wheat, and 10 grams of licorice in water. Take it twice a day in the morning and evening. It is suitable for those with early ovarian failure who have symptoms such as hot flashes, sweating, irritability, palpitations, depression, and a pale complexion.

·Boil lotus seeds and lily rice for porridge, twice a day in the morning and evening. It is suitable for those with early ovarian failure who have symptoms such as palpitations, insomnia, amnesia, weakness, and rough skin.

·Take equal portions of mulberry seeds, wolfberry fruits, and red dates, decocted in water, twice a day in the morning and evening; or use 30 grams of Chinese yam and 100 grams of lean meat to make soup, once a day. It is suitable for those with early ovarian failure who experience dizziness, lack of appetite, fatigue, and pale complexion.

2. What foods should women with absent ovarian function eat for good health:

·It is advisable to choose foods high in protein, vitamins, low in fat, cholesterol, and salt for the health of the ovaries. Diets high in fat and cholesterol are likely to lead to atherosclerosis of the ovarian artery, causing atrophy and变性 of the ovaries, while high-salt diets affect fluid metabolism. It is recommended to consume the following foods regularly: lean meat, dairy products, mushrooms, fruits, vegetables, winter melon, watermelon, mung beans, and red beans. Additionally, incorporating some alkaline foods can help alleviate the stimulation of metabolic acidic products, benefiting ovarian health.

· It is best to eat light, soft, and warm foods. It is recommended to eat more nutritious light foods, such as fruits, vegetables, legumes, coarse grains, etc.

· It is also recommended to eat more vegetables and fruits to maintain a large intake of vitamin E and vitamin B2. Foods like lotus seeds and black fungus are good for tonifying the body. Adding appropriate physical exercise and maintaining a peaceful mindset is the true secret to youth.

· B vitamins can stabilize mood, help sleep, and make people energetic, and they can also alleviate abdominal pain. Especially vitamin B6, which can adjust the function of vegetative nerves and relieve symptoms. Foods rich in vitamin B6 include animal liver, tuna, sardines, soybeans, mushrooms, etc. In addition to food, appropriate supplementation of vitamin B6 preparations is often necessary for severe dysmenorrhea. Supplementing potassium and magnesium before the period can make you feel better. Because the body's demand for these two elements will greatly increase in the late menstrual period. Potassium can moderate mood, inhibit pain, prevent infection, and reduce menstrual blood loss. Magnesium can regulate the psychology after the period, help the body relax, and reduce stress. After the onset of menstruation, you can eat some sour foods such as sauerkraut and vinegar, which can relieve pain.

· It is also recommended to eat more honey, bananas, celery, sweet potatoes to maintain smooth defecation, which can avoid constipation-induced dysmenorrhea and increase pain. If the menstrual blood volume is not much, you can also drink some wine in moderation, which can relieve pain by relaxing smooth muscle and dilating blood vessels. Citrus, shepherd's purse, coriander, carrots, banyan, ginger, and other fruit and vegetable products have the effect of regulating Qi and promoting blood circulation and are a good choice for vegetarian meals during the period.

3. Foods that women with the syndrome of ovarian dysfunction should avoid: Avoid a high-salt diet, do not eat or eat less salted vegetables, salted meat, ham, sausage, bean paste, etc. Limit spicy foods, such as coffee, alcohol, tobacco, tea, cola drinks, etc. Avoid various spicy seasonings.

(The above information is for reference only, please consult a doctor for details.)

What should be noted before the treatment of the syndrome of ovarian dysfunction?

Prevention:

Hospitals should try their best to prevent the occurrence of iatrogenic diseases in the treatment of patients' diseases.

The treatment methods for the syndrome of ovarian dysfunction in traditional Chinese medicine

The main treatment for benign conditions is Western medicine, and detailed treatment with traditional Chinese medicine requires consultation with a doctor. The treatment methods for the syndrome of ovarian dysfunction include medication therapy, which is mainly hormone therapy. Estrogens have three types: natural, synthetic, and metabolites. The administration routes can be oral and injection methods. There are also tablet, capsule, injection, ointment, and patch formulations, with different prices and usage, which can be selected according to specific conditions. No treatment is needed before puberty. The use of estrogen and progesterone cyclic therapy in women during puberty and the childbearing period is better than using estrogen alone.

1. Hormone Replacement Therapy

In those castrated before puberty, after entering puberty, the main function is to promote the development of reproductive organs and secondary sexual characteristics, and regular use of sex hormones to simulate the normal menstrual cycle. The purpose of using sex hormones in women of childbearing age is on the one hand to alleviate symptoms, and on the other hand to delay aging and improve the quality of sexual life.

(1) Estrogen Therapy: The commonly used estrogens in China include Diethylstilbestrol, Ethinyl Estradiol, Norethindrone, Compound Medroxyprogesterone Acetate (Fufu Chun), Gai Fu Run, Conjugated Estrogen (Bimel), Toremifene (Libelle) and others. Give Diethylstilbestrol 0.5mg, or Conjugated Estrogen (Bimel) 0.625mg, Estradiol Valerate 1-2mg, once a day, add progesterone for a total of 25 days starting from the 15th day of taking medication, and start another treatment cycle 5 days after menstruation.

(2) Continuous Low-Dose Therapy of Estrogen and Progesterone: When estrogen is used for a long time, the use of progesterone can reduce side effects, promote protein synthesis, enhance physical fitness, and prevent osteoporosis.

(3) Young patients should also use thyroxine and adrenal cortical hormones.

2. Androgen Therapy

Androgens have the effects of maintaining sexual function and inhibiting gonadotropins. In regulating autonomic nerve function, their effects are not inferior to those of estrogens. However, when used in large doses for a long time, they can cause androgenization side effects, which should be paid attention to.

3. Combination Therapy of Estrogen and Androgen

Suitable for women of advanced childbearing age, the two hormones have a synergistic antagonistic effect, can reduce the side effects caused by the use of each hormone alone, and have a synergistic effect on the inhibition of gonadotropins, and promote protein synthesis and metabolism, enhance physical fitness and prevent osteoporosis.

4. Application of Male and Female Hormone Precursors or Intermediate Metabolic Products such as Estrone 4-8mg/d, once a day, which can control symptoms without causing endometrial proliferation and a low incidence of adenocarcinoma.

5. Autonomic Nervous System Modulators or Psychotropic Agents such as Oryzanol, Vitamin B6, Ginkgo Biloba,逍遥散, Vital Source, Beauty Tablets, Glutamic Acid, Tranylcypromine, Diazepam, etc., to regulate nervous and mental symptoms.