1. Abnormal development and underdevelopment of the bladder
The absence of bladder development is often accompanied by renal agenesis, so there are very few survivors. In a group of 19,046 post-mortem data, there were 7 cases. There are 25 cases in the literature. Underdeveloped bladder refers to retaining the cloaca, caused by the septal obstruction of the urachus. The ureters terminate in the rectum.
2. Duplicated bladder
It is the result of embryonic developmental disorders, caused by a part of the embryonic tail being affected, often accompanied by posterior intestinal duplication. It can be divided into left and right, anterior and posterior, or upper and lower two bladders, gourd-shaped or polycystic bladder. In a group of 18 cases, 50% were accompanied by lower gastrointestinal duplication anomalies, and in a group of 20 cases with posterior intestinal duplication anomalies, 60% had duplicated bladders. The incidence of duplicated external genitalia is also high. Urinary tract obstruction and infection symptoms may occur, and a treatment plan must be formulated after a comprehensive examination based on the condition of the bladder lesions and other specific congenital anomalies of the organs, including relieving urinary tract obstruction, preserving bladder function,整形 and correcting gastrointestinal anomalies.
3. Bladder diverticula
Due to the presence of congenital localized weaknesses in the bladder wall, and the presence of obstructive factors in the lower urinary tract during fetal development, the intravesical pressure increases, causing the bladder wall to protrude between the detrusor muscle bundles, forming diverticula. However, there may also be no anatomical obstruction at the bladder neck and urethra. Therefore, its formation is related to the abnormal arrangement of bladder muscle fibers. It is more common in males and is often solitary, most located near the ureteral orifice. After the formation of the diverticula, they become increasingly filled and enlarged with each urination, eventually leading to the ureter being pulled into the diverticulum, causing the disappearance of the submucosal segment and the interstitial segment of the oblique ureter, resulting in vesicoureteral reflux. Bladder diverticula are often discovered during further urological examination due to urinary tract infection or difficulty urinating. Diagnosis mainly relies on urography, which can show the shape and position of the bladder diverticula. Bladderoscopy may be supplemented when necessary. Treatment mainly involves relieving lower urinary tract obstruction, controlling infection, and performing diverticulectomy, or adding a urinary bladder-ureteral reanastomosis to prevent reflux.
4. Bladder exstrophy
Bladder exstrophy and urethral cleft complex deformity is caused by developmental abnormalities during the 4th to 10th weeks of embryogenesis. Due to the excessive development of the cloacal membrane, it blocks the migration of mesenchymal tissue and the normal development of the lower abdominal wall. The time and location of the rupture of the cloacal membrane are different, leading to a series of deformities from penile-type urethral cleft to cloacal exstrophy. The typical bladder exstrophy is only a part of this type of deformity, accounting for about 50%, with an incidence rate of about 1 in 10,000 to 50,000 newborns, twice as common in males as in females. The risk of exstrophy in their offspring is 500 times higher than that in the general population, but the genetic type has not been determined yet.