Benign paroxysmal peritonitis syndrome

　　The etiology of benign paroxysmal peritonitis syndrome is unknown, and it may be a familial autosomal recessive genetic disease, which is a type of amyloidosis. It is characterized by congestion and edema of the peritoneum, with scattered fibrinoid material deposition or amyloid protein deposition, accompanied by a small amount of exudate, which contains serous fibrin, neutrophils, and lymphocytes. At the same time, other organs throughout the body, such as the liver, spleen, kidneys, heart, and lungs, may also have amyloid protein deposition.

　　Benign paroxysmal peritonitis syndrome often accompanies urticaria, polyneuritis, and polyserositis, etc., which seriously affects people's health, so once symptoms are found, it is necessary to seek medical treatment in a timely manner.

　　Benign paroxysmal peritonitis syndrome is mainly manifested by paroxysmal fever or irregular fever; abdominal pain and distension, which can be diffuse or localized to a certain area; it is often accompanied by chest pain, joint pain, and neurological dysfunction, with attacks mostly呈 intermittent and periodic, symptoms can be completely relieved during the inter-attack period, and female patients often have attacks during the menstrual period; physical examination findings include abdominal tenderness, liver enlargement, and positive signs of ascites.

　　Benign paroxysmal peritonitis syndrome is a genetic disease, referring to the abnormality of offspring's traits caused by abnormal genetic material (DNA) in the zygote or abnormal genetic information carried by germ cells. The most fundamental way to prevent this disease is to do a good job of prenatal examination and handle abnormalities in a timely manner if any are found.

　　The clinical manifestations of benign paroxysmal peritonitis syndrome are complex, and a comprehensive and systematic examination is required to make a diagnosis.

　　1. During the attack, the white blood cell count is often elevated, the erythrocyte sedimentation rate increases, and α2-globulin increases; urinary protein is positive, and there may be cast urine.

　　2. When the liver is involved, there may be mild abnormal liver function.

　　3. Thoracic and abdominal fluid examination shows serous fibrinous nature.

　　4. Congo red test: After intravenous injection of 1% Congo red solution and 0.22ml/kg body weight, 10ml of venous blood is collected 4 minutes and 1 hour later, respectively, for colorimetric examination. The percentage of dye remaining in the serum is significantly reduced, and pathological examination of living tissue shows amyloid protein deposition.

　　Patients with benign paroxysmal peritonitis syndrome have no special dietary requirements, but it is recommended that patients eat light, with less salt, sugar, fat, and spicy foods, eat more fresh fruits and vegetables, and have a reasonable diet with rich nutrition.

　　In the treatment of benign paroxysmal peritonitis syndrome, colchicine (Colchicin) can be used to reduce the frequency of attacks. The daily dose during an attack is 1.2～1.8mg/kg, diluted and administered slowly by intravenous injection 2～3 times. After the frequency of attacks decreases, the daily maintenance dose is 0.6mg/kg body weight, and long-term prophylactic treatment (2～3 years) should be carried out. Due to the side effects of this drug such as teratogenicity, bone marrow suppression, and sperm deficiency, it should be used with caution. Some people believe that it is only used for patients with significantly restricted activity. In addition, there are reports of using dimethylphosphate (Dimothylphoxide). Adrenal cortical hormones can also be tried to relieve symptoms during an attack. In addition, it is necessary to strengthen supportive treatment.