Darmviren71type was first identified in1969~197was isolated from a second outbreak of central nervous system infection in California, USA, in197has been spreading around the world since the year 0;1972in Australia caused an outbreak mainly characterized by meningitis;1973in Japan caused an outbreak mainly characterized by hand, foot, mouth disease and (or) aseptic meningitis, in Sweden caused an outbreak mainly characterized by aseptic meningitis, accompanied by a few outbreaks of hand, foot and mouth disease; EV71in1969was first isolated from the fecal specimen of an infant with central nervous system disease in California, in1974was identified and named. Since then, many countries have reported EV71of China. EV was first discovered in mainland China.71The type of infection was identified in1987In winter, a hand, foot and mouth disease outbreak occurred in Hubei Province, China.1995年武汉市病毒研究所从手足口病患者中分离出EV71,之后的多次爆发流行经检验均为EV71感染所致。