1. Types of pathogens Currently, it is believed that the vaginal ecosystem during pregnancy and puerperium is extremely complex, with a large number of aerobic bacteria, anaerobic bacteria, fungi, and chlamydiae, mycoplasmas, etc.寄生, but anaerobic bacteria are dominant. In addition, many non-pathogenic bacteria can also cause disease in specific environments.
(1) Aerobic Streptococcus: Beta-hemolytic streptococci can be divided into 18 groups. Group B Streptococcus (GBS) produces exotoxins and tissue-necrotizing enzymes, making it highly pathogenic and virulent, closely related to puerperal infection, and can cause severe infections. Its clinical characteristics include early fever (on average 11 hours postpartum), body temperature over 38°C, chills, rapid heart rate, abdominal distension, poor uterine involution, tenderness in the parauterine or adnexal area, and even sepsis. Aerobic Streptococcus is the main pathogenic bacteria of exogenous infection.
(2) Escherichia coli: Escherichia coli and its related Gram-negative bacilli, Proteus, are the main bacterial species responsible for exogenous infections and are the most common pathogens of sepsis and septic shock. Escherichia coli resides in the vagina, perineum, and urethral orifice and can rapidly multiply and cause disease during the puerperium. The sensitivity of Escherichia coli to antibiotics varies greatly in different environments, and drug sensitivity tests are required.
(3) Staphylococcus: The main pathogenic bacteria are Staphylococcus aureus and Staphylococcus epidermidis, which have significant differences in pathogenicity. Staphylococcus aureus is mainly an exogenous infection, which can easily cause severe wound infections. Staphylococcus epidermidis exists in the vaginal flora and causes relatively mild infections. Staphylococcus is resistant to penicillin due to its ability to produce penicillinase.
(4) Anaerobic Streptococci: Diphtheroids and Sarcinae are more common, existing in the normal vagina. When the birth canal is injured, residual tissue necrosis, local redox potential is low, and the bacteria rapidly multiply, mixed with Escherichia coli infection, emitting an abnormal foul smell.
(5) Anaerobic Bacilli: A group of strictly anaerobic Gram-negative bacilli, including Bacteroides fragilis, Bacteroides pigmentans, etc., which have the characteristic of accelerating blood coagulation and can cause thrombophlebitis of the adjacent area.
In addition, Clostridium botulinum and Neisseria gonorrhoeae can also cause puerperal infection, but they are less common. Mycoplasma and Chlamydia can also be one of the pathogens causing puerperal infection.
2. Source of Infection There are two sources of infection: one is self-infection, which refers to pathogens that寄生 in the reproductive tract or other parts of normal pregnant women. They can cause disease when infection triggers occur; the other is external infection, which is caused by contact with contaminated clothing, utensils, various surgical instruments, and items after being contaminated.
2. Infection Etiology The response of the body to invasive pathogens depends on the type, quantity, virulence of the pathogens, and the body's defense ability. Any factor that weakens the reproductive tract and overall defense ability of the mother is conducive to the invasion and reproduction of pathogens. For example, anemia, malnutrition, chronic diseases, the proximity to the expected delivery date, premature rupture of membranes (the amniotic fluid contains lysozyme with bactericidal activity, which decreases after the amniotic fluid is lost), amniotic cavity infection, various obstetric surgical procedures, birth canal injury, bleeding before and after birth, uterine cavity packing, birth canal foreign bodies, prolonged labor, placental retention, and others can all become etiological factors for puerperal infection.