Fetal hydrops syndrome is a fetal abnormality that is extremely lethal. It occurs in the early stages of the fetus and infant, characterized by severe edema of the entire body's soft tissues, with a large accumulation of fluid in the thoracic and abdominal cavities, enlargement of the heart, liver, and spleen. In severe cases, it can lead to fetal death or the appearance of symptoms such as hemolysis and kernicterus after birth. The perinatal mortality rate is very high, and fetal hydrops, large placenta, increased uterine tension, are prone to cause serious complications such as preeclampsia and postpartum hemorrhage in pregnant women.
The incidence of hydrops fetalis is approximately 1 in 1400 to 4000 pregnancies, and there are two types: immunological and non-immunological. Immunological hydrops refers to immune hemolysis of the fetus or newborn baby caused by incompatibility between the blood types of the pregnant woman and the fetus, which is a type of alloimmune hemolytic disease. It is mainly caused by incompatibility between the ABO and Rh blood types. Although the fetus has its own protective mechanisms, pregnant women still need to pay attention to regular prenatal examinations, blood type antibody screening, and ultrasound monitoring. It has been reported that the incidence of hemolytic disease caused by ABO incompatibility accounts for about 2 to 2.5%. Rh incompatibility is 5%. Cardiovascular malformations and functional abnormalities - incomplete atrioventricular valve, heart failure, large blood vessel malformations, chromosomal abnormalities, placental abnormalities, blood transfusion syndrome caused by vascular anastomosis between the fetus and the mother or twins, blood factors (such as thalassemia), fetal pulmonary malformations, and intrauterine infection with bacteria and viruses (such as parvovirus, streptococcus, spirochete, cytomegalovirus, enterovirus, toxoplasma, etc.).