Prevention: Strengthen prenatal examination, actively prevent and treat pregnancy-induced hypertension; strengthen management for high-risk pregnancy with complications such as hypertension and chronic nephritis; avoid supine position and abdominal trauma in the late pregnancy; when performing external version to correct the fetal position, the operation must be gentle; avoid a sudden decrease in uterine cavity pressure when dealing with excessive amniotic fluid or twins during delivery.
First, the method of treating ectopic pregnancy in traditional Chinese medicine
1. Traditional Chinese medicine treatment:According to the principle of Bayin syndrome differentiation, ectopic pregnancy belongs to the syndrome of blood stasis in the lower abdomen, where pain indicates blockage of the meridians, and is an excess syndrome. Therefore, the principle of treatment should be to activate blood circulation, remove blood stasis, and relieve pain, combined with the patient's differentiation of cold, heat, deficiency, and excess, and combined with clinical typing (shock type, stable type, mass type) for medication.
(1) Shock type:In cases of internal bleeding, pay attention to both deficiency and excess, and take into account the patient's body constitution in terms of cold and heat. Because ectopic pregnancy itself is an excess syndrome, and internal bleeding, decreased blood pressure, pale complexion, cold sweat, and weak pulse are deficiency symptoms, the analysis should be based on the patient's condition at the time. If the deficiency is severe, use Ginseng to tonify Qi to prevent blood deficiency, and assist with activating blood circulation and removing blood stasis to promote the absorption of internal bleeding.
Prescription:Danshen 30g, Chishao 10g, Taoren 10g, Ruixiang 10g, Muyao 10g. Boil in water to make 300ml, and take in two doses. For those with severe deficiency, add Ginseng; for those with severe pain, add Yuanhu, and simultaneously rescue from shock, transfuse blood, administer intravenous fluids, provide oxygen, keep warm, and maintain systolic blood pressure around 12kPa.
During the treatment process, it is necessary to closely observe the patient's pulse, blood pressure, abdominal pain, and hemoglobin levels to determine whether to continue internal bleeding treatment; the patient must absolutely rest in bed and avoid early activities, as well as to minimize sudden changes in body position and increase abdominal pressure. Treatment should be carried out under conditions where blood transfusion is available and laparotomy can be performed at any time. This type is suitable for immediate surgical treatment, and for some patients who have refused further surgery after multiple abdominal operations, it can be considered.
(2) Stable type:The condition is stable, blood pressure is stable, abdominal pain is reduced, the free blood in the peritoneal cavity has formed a mass or partially absorbed, the tenderness and rebound pain in the abdomen are reduced, and the mobile dullness gradually disappears. Vaginal examination may feel the mass. According to the main formula, appropriate cooling and detoxifying herbs such as Scutellaria baicalensis, Flos lonicerae, and Forsythia suspensa can be given to prevent infection. At this stage, bed rest is still the main treatment, and appropriate activities are gradually increased.
(3) Mass type:This type is characterized by blood stasis in the lower abdomen with mass. In addition to using the main formula to promote blood circulation and remove blood stasis, drugs for softening and breaking hard masses should be added to eliminate the mass. Three kinds of rhizoma Curcumae are used, which are good at breaking masses. However, attention should be paid to the hard drugs such as rhizoma Curcumae, as prolonged use may cause deficiency syndrome. Therefore, according to the symptoms and pulse, herbs such as Codonopsis and Astragalus should be given to tonify Qi. To accelerate the absorption of the mass, an external application of softening ointment can be given: 15g of Semecarpus anacardium, 15g of Momordica charantia, 15g of copper green, 10 dates with the kernel removed, mixed evenly, ground into fine powder, wrapped in gauze, placed on the lower abdomen, and externally heated. Or 0.6g of musk, 6g of camphor, 9g of dragon's blood, 9g of rosin, and 9g of silver bead. The last four drugs are ground into fine powder, spread on a cloth, heated with fire, and finally, musk is added and externally applied to the mass on the lower abdomen.
For those with positive pregnancy test but not terminated, two centipedes, 15g of achyranthes, 9-15g of trichosanthes, and 9g of tooth soap can be added to eliminate the embryo, making the pregnancy test negative. However, the effect is not very satisfactory. Treatment can also be carried out under the monitoring of β-hCG and B-ultrasound, and MTX can be added simultaneously to accelerate the termination of the gestational sac.
2. Western medical treatment methods for tubal pregnancy
1. Drug treatment:Methotrexate (MTX) is mainly used for unruptured tubal pregnancy, with intact serosal of the fallopian tube, no active bleeding, the diameter of the gestational product at the site of tubal pregnancy is less than 3-4cm, less than 100ml of blood in the peritoneal cavity, β-hCG less than 3000mIU/ml, stable vital signs, young, and desiring fertility.
Method of administration: (1)MTX oral 0.4mg (kg?d), 5 days as a course of treatment. The general dose is 25mg/d, used for 5 days, without toxic reactions, and rarely used in clinical practice; (2) MTX intramuscular injection 0.4mg/(kg?d), 5 days as a course of treatment. Some authors reported 23 cases of ectopic pregnancy, after treatment, 95.7% of the gestational sacs were absorbed, and 10/19 (52.6%) patients were confirmed to have patent fallopian tubes by contrast or laparoscopy; (3) MTX-CF regimen, formyl tetrahydrofolate (citrovorum factor, CF), CF can reverse the toxic effects of MTX, which is currently the most commonly used method. When the dose of MTX is 1mg/kg, the plasma concentration reaches 10-8M, CF must be used to rescue in order to achieve high efficacy and low toxicity. The infusion time of MTX intravenously is less than 4 hours, CF is 1/10 of MTX, and the interval between the two is 24 hours; (4) Local injection of MTX, inject MTX into the gestational sac under the guidance of ultrasound; or inject into the fallopian tube directly under the observation of laparoscopy. During the process of drug therapy, it is necessary to closely observe abdominal pain, vital signs, and drug toxicity reactions. β-hCG and B-ultrasound are used to monitor the local condition of the fallopian tube.
2. Surgical treatment:
(1) Fallopian tube resection:Whether it is an ectopic pregnancy with流产 or rupture of the fallopian tube, the removal of the fallopian tube can stop bleeding in time and save lives. In women who already have children and no longer wish to bear children, ligation of the opposite fallopian tube can be performed simultaneously. If the fallopian tube lesion is too large, the incision is too long, and it involves the fallopian tube mesentery, blood vessels, and/or vital signs are in a serious state, the fallopian tube should also be removed. In conservative surgery, if the fallopian tube bleeding cannot be controlled, the fallopian tube should be removed immediately.
The operation can be performed under needle anesthesia or local anesthesia. After laparotomy, hemostasis should be performed first, and the bleeding point should be clamped with forceps to stop bleeding. Rapid blood transfusion should be given during shock, and then proceed with the step-by-step removal of the affected fallopian tube after the shock improves. If the ovary on the same side is normal, it should be preserved. If the opposite fallopian tube is normal and the patient requests sterilization, ligation should be performed. If there is damage to the opposite fallopian tube, the treatment should be based on the patient's condition, requirements, and the nature of the lesion. In principle, the operation time should be kept as short as possible, and it should not be considered to perform a fimbriae ostomy during acute hemorrhagic shock or in the presence of inflammation. If there is no obvious infection in the free abdominal blood, autologous blood transfusion can be performed, especially in cases where blood sources are scarce. Autologous blood transfusion is an extremely effective measure for抢救 hemorrhagic shock. At this time, the blood does not coagulate, has no viscosity, and no smell. Under the microscope, the destruction of red blood cells does not exceed 30%. Add 10ml of 3.8% sodium citrate to every 100ml of blood, and for autologous blood transfusion of 500ml or more, add 10-20ml of 10% calcium gluconate to prevent citrate poisoning. Autologous blood transfusion does not require blood matching and can promptly replenish blood volume, which is very necessary for severely shocked patients with internal hemorrhage. It can save blood from the blood bank, reduce economic burden, and the red blood cells in the autologous blood are fresh, with strong oxygen-carrying capacity, and can also avoid infectious diseases such as serum hepatitis. In recent years, some people have proposed that autologous blood transfusion can be performed without anticoagulants and applied clinically, but the degree of coagulation of the recovered blood transfusion varies from person to person. To fully utilize the advantages of autologous blood transfusion, it is advisable to add sodium citrate or ACD solution as anticoagulant.
(2) Conservative Surgery:So-called conservative surgery, in principle, is to remove the extrauterine pregnancy material, try to preserve the anatomy and function of the fallopian tube, and create conditions for future intrauterine pregnancy.
Indications:The current fallopian tube pregnancy in the young woman is her first pregnancy; one fallopian tube has been removed due to the lack of children.
Surgical Methods:Tubal incision and embryo removal surgery, at the dilated site of the affected side, cut 1 to 2cm parallel to the longitudinal axis of the fallopian tube on the serosal surface, gently push out the pregnancy material, and then suture the incision under the microscope with fine silk thread or 0/8 non-traumatic suture. It can also be performed by window surgery, that is, not closing the incision, but intermittently suturing the incision margin to stop bleeding, forming a 'window'. If it is a cornual pregnancy, the diseased end can be excised and anastomosed end-to-end, and tubal cornual implantation surgery can be performed near the uterine cornu.
Preventing adhesions after surgery is one of the important measures to preserve fertility, and 250 to 300ml of medium molecular weight dextran or 100ml of 0.25% procaine, 250mg of hydrocortisone, and 10ml of glycerol can be placed in the peritoneal cavity. Postoperative treatment is also very important for the recovery of fertility, such as timely tubal irrigation, traditional Chinese medicine treatment for activating blood and removing blood stasis, etc.
(3) Laparoscopic Surgery:Firstly, use a syringe to flush and aspirate the accumulated blood in the pelvic cavity under laparoscopy to find the implantation site of the ovum. If it is a fundal pregnancy, the pregnancy material can be directly aspirated or clamped out from the fundus (through the fimbria), or a large spoon forceps can be used. If it is a cornual or stromal pregnancy, then tubal incision surgery is required. Inject 5% POR-820 to 30ml locally to cause ischemia, which can prevent bleeding during tubal incision, and then cut the tubal wall after electrocoagulation at the tubal convex area on the back of the tube, until the pregnancy material is exposed. After separating the tubal wall with two non-traumatic instruments, slowly remove the pregnancy material with a large spoon forceps, and finally flush the implantation site with a syringe. Suture the serosa of the tube with intraperitoneal knotting method to close the wound.