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Seminal fluid non-liquefaction

  Seminal fluid non-liquefaction restricts sperm motility, slows down or inhibits the entry of sperm into the uterine cavity for fertilization, causing infertility. Increased viscosity of seminal fluid affects sperm vitality and survival rate. At the same time, the protein-dissolving enzymes contained in seminal fluid can liquefy thick cervical mucus, so an increase in seminal fluid viscosity can also affect the ability of sperm to penetrate cervical mucus, leading to infertility. The reason why seminal fluid solidifies into a gelatinous state is due to the coagulating protein secreted by the seminal vesicle. The protein-hydrolysing enzymes and fibrinolytic enzymes secreted by the prostate in seminal fluid can decompose this coagulating protein, promoting seminal fluid liquefaction. Therefore, seminal fluid non-liquefaction is caused by an increase in coagulating protein or a decrease in protein-hydrolysing enzymes and fibrinolytic enzymes. During seminal fluid analysis, if seminal fluid is in a non-coagulated state, it may be due to an defect in the ejaculatory duct or congenital absence of the seminal vesicle.

Table of Contents

1. What are the causes of seminal fluid non-liquefaction?
2. What complications can seminal fluid non-liquefaction easily lead to?
3. What are the typical symptoms of seminal fluid non-liquefaction?
4. How to prevent seminal fluid non-liquefaction?
5. What laboratory tests need to be done for seminal fluid non-liquefaction?
6. Dietary recommendations and禁忌 for seminal fluid non-liquefaction patients
7. Conventional western treatment methods for seminal fluid non-liquefaction

1. What are the causes of seminal fluid non-liquefaction?

  Traditional Chinese medicine believes that the true cause of seminal fluid non-liquefaction lies in the liver and kidney. If there is Yin deficiency, internal heat may arise, consuming seminal fluid; or if the original Qi is weak and kidney essence is depleted; or if the liver is stagnant and transforms into fire, disturbing the seminal palace, all of these can affect the normal liquefaction of seminal fluid, leading to infertility. Seminal fluid non-liquefaction is often caused by cold congealing, heat burning, phlegm obstruction, or blood stasis, and its etiology and pathogenesis commonly include the following:

  1. Deficiency of congenital kidney Yang, or lack of postnatal nourishment, chronic illness, or severe damage to kidney Yang, or invasion of external cold pathogens, can all lead to cold congealing of seminal fluid, preventing its liquefaction.

  2. Overindulgence in alcohol, sexual activities, and excessive physical or mental strain, or the transformation of the five emotions into fire, can all consume kidney Yin, leading to Yin deficiency and fire excess, burning and drying up body fluids, resulting in thick seminal fluid that does not liquefy.

  3. Generally, excessive consumption of spicy, sweet, and greasy foods, internal damp-heat, or external invasion of damp-toxin can scorch body fluids, causing seminal fluid to become thick and unliquefied.

  4, Overeating of cold and cool drinks, damaging the spleen Yang, or other diseases injure the spleen Yang, spleen deficiency and kidney; or kidney Yang deficiency leading to spleen Yang deficiency, spleen and kidney Yang deficiency, then water dampness cannot be transformed, blocked to form phlegm, phlegm dampness stuck in the seminal orifice, Qi transformation is not smooth, then semen cannot be liquefied.

  5, Qi deficiency and blood stasis or blood stasis constitution, seminal orifice obstruction, semen does not liquefy.

  Modern medicine believes that the most common cause of sperm liquefaction failure is insufficient fibrinolytic enzyme secretion by the prostate due to seminal vesiculitis and prostatitis; deficiency of trace elements (magnesium, zinc, etc.); congenital absence of the prostate, etc.

  It is generally believed that the secretions of the seminal vesicle and prostate participate in the coagulation and liquefaction process of semen. The coagulating factors produced by the seminal vesicle cause the semen to coagulate, while the proteinase, fibrinolytic protease, and other liquefying factors produced by the prostate cause the semen to liquefy. Once inflammation occurs in the seminal vesicle or prostate, it can cause the secretion of these factors to be impaired, leading to an increase in coagulating factors or a decrease in liquefying factors, forming sperm liquefaction failure.

  Therefore, the key to treating sperm liquefaction failure lies in the根治 of seminal vesicle and prostatic diseases. Most patients will improve their sperm liquefaction failure after the cure of prostatic and seminal vesicle diseases.

 

2. What complications can sperm liquefaction failure easily lead to

  Impact on Fertility

  However, if the semen does not completely liquefy within 30 minutes after ejaculation, it is called delayed liquefaction, which has some impact on fertility; if it does not liquefy after more than 1 hour, it is called sperm liquefaction failure. Sperm is trapped in the semen, just like a person swimming in mud and unable to move, which is one of the common causes of male infertility.

  The coagulation and liquefaction of semen are mainly balanced and regulated by the liquefying factors and coagulating factors secreted by the prostate and seminal vesicle. When the prostate has problems, such as inflammation or secretory dysfunction (low androgen levels, etc.), it can lead to sperm liquefaction failure.

  Since sperm liquefaction abnormalities may be accompanied by prostatitis and other reproductive tract infectious diseases, the fundamental way to improve sperm liquefaction failure is to carry out anti-infection treatment while taking drugs to improve the secretory function of the prostate. For patients who are ineffective with the above methods of treatment, it can be considered to preprocess the semen in vitro before artificial insemination by husband (AIH).

  Disease Harm

  Sperm liquefaction failure generally cannot lead to pregnancy for the female partner. Sperm liquefaction failure is often caused by prostatic diseases. When inflammation occurs in the prostate or seminal vesicle, due to the lack or destruction of proteinase secretion, the enzyme system is disrupted, causing some patients' semen to not liquefy even after 1 hour, or not fully liquefied, with too high viscosity, making the problem very serious. This is called sperm liquefaction failure, which is a pathological phenomenon. In this case, sperm cannot move, and it can cause infertility. Therefore, seminal vesicle and prostatic diseases are important causes of liquefaction failure. 90% of patients with sperm liquefaction failure have prostatic dysfunction, among which the most common cause is prostatitis, leading to a decrease in the secretion of liquefying enzymes and the occurrence of liquefaction failure. In addition, diseases such as varicocele can cause dysregulation of testicular endocrine function, a decrease in testosterone secretion, leading to a decrease in the secretory function of accessory glands, which can also form the phenomenon of sperm liquefaction failure, thus affecting sperm vitality.

  Normal sperm not liquefying is beneficial for staying in the female vagina. The seminal fluid just ejaculated is initially in a solid state, at this time, the sperm is inactive. Subsequently, the solid seminal fluid will liquefy in a short period of time, and the sperm will start to move. Under normal circumstances, this process will not exceed one hour. If it exceeds, it is seminal fluid not liquefying, which will lead to long-term restriction of sperm movement and cause infertility.

3. What are the typical symptoms of sperm not liquefying

  The manifestations of sperm not liquefying usually are:

  1. The seminal fluid will be more viscous or present a jelly-like state, and there will be sheets, lumps, and clumps. It does not liquefy outside the body for more than an hour.

  1. There are symptoms of ejaculation difficulties, accompanied by ejaculation pain, blood seminal fluid, and even impotence, premature ejaculation, and seminal emission.

  2. It can lead to poor mental state, neurasthenia, such as insomnia, palpitations, dizziness, fatigue, and so on. Moreover, some complications may also occur.

 

4. How to prevent sperm from not liquefying

  1. Stay away from radiation

  Radiation is a form of radiation pollution, and its harm should not be underestimated. This is because excessive exposure to radiation can cause spermatid chromosome abnormalities.

  2. Pay attention to indoor decoration

  Pay attention to indoor decoration: formaldehyde has a strong damaging effect on the genetic material within cells. It is a volatile organic substance, and various decorative materials contain it to varying degrees. Therefore, when selecting decorative boards, it is necessary to choose qualified materials with low formaldehyde content.

  In addition, benzene (commonly found in paints, coatings, and adhesives) is also an important source of pollution. Pay attention not to purchase coatings or adhesives containing benzene. It is best to open the windows and doors for one summer after house decoration, and then move in to live.

  Granite contains a radioactive substance called radon. Radon is one of the rare gas elements and is a product of the decay of radioactive elements such as radium and thorium. The radon produced from radium is a colorless gas with a half-life of 3823 days. Long-term exposure to radon is harmful to health and can kill sperm, leading to infertility.

  3. Drug Pollution

  The frequent use of sedatives, antitumor drugs, and chemicals such as busulfan, furan drugs, and hormone drugs can cause spermatogenic disorders, spermatid chromosome damage, and breakage.

  Moreover, it is important to pay attention to eating more high-quality proteins such as beef and fish in daily life, exercise regularly, live a regular lifestyle, and try not to smoke or drink, avoid taking hot baths, and so on.

 

5. What laboratory tests are needed for spermatic liquefaction

  1. To check for spermatic liquefaction, immunological examination should be performed:Immunological examination can determine the presence of autoimmune diseases, karyotype analysis can determine the presence of chromosomal abnormalities. The determination of serum FSH, LH, T, PRL is an important method for checking oligospermia and also helps to distinguish between primary testicular failure and secondary testicular failure.

  2. To check for spermatic liquefaction, biochemical examination of seminal fluid should be performed:Currently, more extensive studies are conducted on acid phosphatase, citric acid, fructose, protein, trace elements, lactate dehydrogenase X, and so on.

  (1) Acid phosphatase: measured by the β-glycerophosphate method. The normal value is 882±412 Buret units/ml. This enzyme mainly comes from the prostate and is related to sperm vitality and metabolism. Sperm-specific enzyme - lactate dehydrogenase X (L-DHX), LDH isoenzyme has relative tissue specificity and is related to spermatogenic function. The level of this enzyme is reduced in male infertility patients who consume too much cottonseed oil.

  (2) Citric acid: measured by the Furthherrmann reaction, the normal value is 56±2.0mg/dl, mainly from the prostate, which regulates the concentration of calcium ions in seminal fluid, affects the liquefaction of seminal fluid, and has the role of an activator of prostate acid phosphatase, thereby affecting sperm vitality. When the prostate is inflamed, the content of citric acid is significantly reduced.

  (3) Protein: measured by the biuret method. The normal value for humans is 3.6±0.8g/dl. The protein in seminal fluid mainly comes from the seminal vesicle and prostate, which can promote sperm vitality and protect sperm from harmful environmental effects.

  (4) Trace elements: play an important role in male reproductive and reproductive endocrine function. The normal concentration of zinc in seminal fluid is 130±56μg/ml, copper: 1.85±0.15μg/ml, iron: 0.81±0.04μg/ml.

  (5) Measurement of fructose: Generally using the resorcinol method, the normal value is 256±104mg/dl. Fructose is mainly secreted by the seminal vesicle and is the main source of energy metabolism for sperm, which is related to sperm viability.

  3. Testicular Ultrasound:This examination can detect gross changes in the testicles, and testicular biopsy can provide more reliable diagnostic and treatment evidence.

6. Dietary taboos for patients with spermatic liquefaction

  Spermatic liquefaction is closely related to zinc deficiency. It is necessary to supplement zinc in a timely manner. Relying solely on food for supplementation is not comprehensive and is not timely, which is also why even if you eat more zinc-rich foods, you may still be deficient in zinc.
  In daily diet, it is advisable to consume more coarse flour, tofu, and other soy products, beef, mutton, fish, lean meat, peanuts, sesame seeds, dairy products, and other foods rich in zinc. Foods rich in selenium include seafood, mushrooms, eggs, garlic, ginkgo biloba, and so on. Once the body does not lack zinc and there are no symptoms, it is enough to pay attention to diet.
  Male infertility due to spermatic liquefaction can severely affect reproductive issues. In addition to identifying the cause and actively treating the condition, patients can also make appropriate dietary adjustments to assist in treatment. The following are two dietary therapies for spermatic liquefaction for reference only:
  1、青虾炒韭菜:韭菜100g洗净,切段,青虾250g洗净,先以素油炒青虾,再加韭菜煸炒,嫩熟即可食用,宜常食。
  2、益气健精汤:山药20g、人参15g。
  3、黄芪20g、麻雀脑5个、母鸡1只。将麻雀脑去毛、母鸡洗净、同煮至七分熟后,加入人黄芪、山药、调料等;人参用开水泡开,蒸半小时,喝汤吃肉嚼人参。
  精子不液化患者在生活中要留意休息,生活规律,戒烟禁酒;尽量少喝可乐、咖啡、少吃芹菜。精子不液化建议多食用西红柿、西瓜、羊肉韭菜、含贝壳类海产品。
.

7. 西医治疗精子不液化的常规方法

  常规治疗方法:
  (1)彻底治疗前列腺炎、精囊腺炎等原发病变,恢复其正常功能。
  (2)用含4%α淀粉酶的生理盐水在性交前冲洗阴道,或在性交后注射1毫升于阴道内。也可将该酶50毫克混入可可脂内作成3厘米长的药栓,性交前塞入阴道内。这一方法的发现是因为有人观察到唾液具有液化精液的作用,并从中得到启发。α淀粉酶不仅具有促进精液液化作用,影响含糖原的阴道或子宫颈分泌物,而且还能成为精子活动的能量来源。因此,这种方法得到广泛应用。
  (3)在精液中加入正常人的精浆,促使液化。但是,首先要确定此精浆不含抗精子抗体,无感染,并且事先经过高速离心,去掉沉淀物和冻融3次的处理。
  (4)将精液射入盛有培养液的容器内,用带18、19号针头的注射器反复抽吸,直至精液稀薄,再经两次离心、洗涤,最后将精子重新悬入一定量的培养液中作人工授精。
  (5)如果精液粘稠度过高,可用分段射精方法,将头三下射出的精液留在阴道内,立即抽出阴茎,将其余精液射在外面。因为后段精液主要含精囊腺分泌液,所以粘稠度较高。

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