Idiopathic acute tubulointerstitial nephritis

　　The etiology of this disease is unknown. The 'renal-eye syndrome' associated with uveitis may be related to chlamydia infection. The clinical manifestations include persistent renal function and tubular function damage, bone marrow and lymphoid granuloma, and at some point in the course of the disease, uveitis may occur. Some cases may develop bone marrow granuloma.

　　Idiopathic acute tubulointerstitial nephritis can lead to complications such as uveitis, anemia, bone marrow granuloma, chronic renal insufficiency, renal concentrating ability disorder, renal sodium retention disorder, renal potassium excretion disorder, and renal endocrine dysfunction.

　　What are the symptoms of idiopathic acute tubulointerstitial nephritis (ATIN)? Briefly described as follows:

　　1. The clinical manifestation of this disease is acute tubulointerstitial nephritis. Unlike drug-induced ATIN, idiopathic ATIN is not often accompanied by rash, increased blood eosinophils, and this disease is accompanied by fatigue, anorexia, nausea, muscle pain, weight loss, mild to moderate anemia, rapid blood sedimentation, and urine examination may show hematuria, leukocyte urine, 24h urine protein below 1.5g, increased blood creatinine and urea nitrogen levels, and some patients with spontaneous ATIN may occasionally occur particularly severe kidney damage.

　　2. In patients with tubulointerstitial nephritis-granulomatous uveitis syndrome, fever is also common. The clinical manifestations include persistent renal function and tubular function damage, bone marrow and lymphoid granuloma, and at some point in the course of the disease, uveitis may occur, and some cases may develop bone marrow granuloma.

　　The etiology of this disease is unknown, and there is no effective preventive measure. However, by paying attention to reasonable diet, actively strengthening physical activities, and continuously improving the body's ability to resist diseases, the occurrence of the disease can be effectively prevented.

　　1. Control the diet structure, avoid excessive intake of acidic substances, and exacerbate acidic体质. The acid-base balance of diet is an important link in the treatment of idiopathic acute tubulointerstitial nephritis and the prevention of complications. In terms of diet, it is necessary to eat more foods rich in plant organic active alkali, eat less meat, and eat more vegetables.

　　2. Participate in aerobic exercise, exercise appropriately, and do more activities in the sun to sweat more, which can help to eliminate excess acidic substances in the body, thereby preventing the occurrence of kidney disease.

　　3. Maintain a good mood and do not have excessive psychological stress. Excessive stress can lead to the deposition of acidic substances, affecting the normal metabolism. Appropriately adjusting one's mood and stress can maintain a weak alkaline体质, thereby preventing the occurrence of kidney disease.

　　4. Live a regular life. People with irregular lifestyles, such as staying up all night to sing karaoke, play mahjong, or not returning home at night, will worsen the acidification of the body.

　　5. Stay away from tobacco and alcohol. Both are typical acidic foods, and excessive smoking and drinking can easily lead to acidification of the human body, making kidney disease an opportunity.

　　Do not eat contaminated foods such as contaminated water, crops, poultry, eggs, etc. Eat some green organic foods and prevent disease from entering through the mouth.

　　What examinations should be done for idiopathic acute tubulointerstitial nephritis (ATIN)? A brief description is as follows:

　　Firstly, laboratory tests

　　1. Levels of IgG, IgE, IgM, and eosinophils in serum increase. Levels of creatinine and blood urea nitrogen increase. Patients with anti-tubular basement membrane antibody (TBM) often have mild anemia, positive C-reactive protein, hypergammaglobulinemia, and increased erythrocyte sedimentation rate (ESR).

　　2. Urinalysis may reveal hematuria, proteinuria, and leukocyteuria, with less than 1.5 grams of protein in 24-hour urine.

　　Secondly, other auxiliary examinations

　　The pathological examination of renal biopsy shows infiltration of interstitial lymphocytes, plasma cells, and eosinophils, deposition of immunoglobulins in the mesangial area, granular IgE and C3 deposition in renal tubules.

　　Patients with idiopathic acute tubulointerstitial nephritis should eat chicken, peaches, scallions, soybeans, pork, chestnuts, agastache, kidneys, broussonetia papyrifera seeds, oyster yellow, deer tendons, deer fetus, deer tails, deer penises, deer horn glue, sea dog kidney, cow kidney, sheep kidney, bull penis, black beans, prepared rehmannia, salt, Wuling Shen, chicken kidneys, duck kidneys, quail, Chinese sparrow, chicken kidney grass, deer衔珠草, etc. Do not eat salty, greasy, or cold foods, maintain regular作息time, and exercise moderately.

　　The following is a brief description of the treatment methods for idiopathic acute tubulointerstitial nephritis:

　　Idiopathic Acute Tubulointerstitial Nephritis (ATIN) treated with corticosteroids has a therapeutic effect on the improvement of kidney and ocular lesions, and the treatment methods and dosages of corticosteroids are the same as those of conventional glucocorticoid therapy. The prognosis of children with idiopathic acute tubulointerstitial nephritis is good regardless of whether they receive hormone therapy. The judgment of the course and prognosis of adult cases should be cautious. In general, adult cases show partial recovery of renal function after several weeks of corticosteroid therapy. Although idiopathic ATIN can be self-healing, a small number of cases may evolve into chronic renal insufficiency.