How is antimony dust沉着症 caused? A brief description is as follows:
1, etiology
Antimony dust pneumoconiosis is lung lesions caused by long-term inhalation of metallic antimony and antimony oxide fumes during the production process. In industry, antimony is mainly used to make alloys, and oxides can be made into pigments for use in porcelain, ceramics, paints, and rubber industries. The mining of antimony ore, especially in the smelting, refining, and alloy production processes, can produce a large amount of antimony fumes.
2, pathogenesis
The effects of antimony dust on pneumoconiosis are controversial. Karajovic(1957) first reported that among workers exposed to antimony oxide dust in a smelter in Yugoslavia,31cases of antimony dust pneumoconiosis, and many scholars have reported nearly a hundred cases of antimony dust pneumoconiosis in succession. Bouffont(1987) reported two cases of lung biopsy specimens from patients diagnosed with antimony dust沉着症, where fibrosis was found around the dust foci. China has abundant antimony reserves, especially in20th century60~7The Guangxi, Guizhou, and Hunan provinces reported3More than 00 cases of antimony dust pneumoconiosis, and have conducted in-depth research on the biological effects of antimony.1983Chinese scholars believe that the impact of antimony dust on the lungs is more severe than that of tin dust, and can cause acute or chronic interstitial pneumonia.
There is little pathological data on antimony dust pneumoconiosis.1967year, Mecallum reported a case of a smelter worker who died of lung cancer. The pathological examination found a large amount of antimony dust deposition in the alveolar spaces, alveolar septa, and around small blood vessels, as well as a response of dust-containing macrophages, with no fibrosis. China has reported four cases of pathological changes in smelter workers who had not been diagnosed with antimony dust pneumoconiosis before death, which were chronic bronchitis, bullous emphysema, fibrosis around small bronchi and alveolar septa, and dust deposition in the hilar lymph nodes.1984Chinese scholars gave rats repeated intratracheal injections of antimony dust, each time50mg/only, after the second dust exposure3months, nodules in the lungs appear with reticular fibers and no collagen fibers; after the fourth dust exposure6After months, nodules appear with collagen fibers; but by9After months, dust foci decrease, showing a reduction or disappearance of lesions, with most of the dust in the lungs being cleared.