Appendicitis during pregnancy is a common clinical complication. The clinical manifestations are atypical, and if doctors do not have rich clinical experience, misdiagnosis is easy, leading to delayed treatment. The appendix is prone to perforation, which can develop into diffuse peritonitis, sepsis, and even septic shock. The prognosis is mainly related to early diagnosis and timely surgical treatment, as well as the gestational age. Antibiotics should be used in combination after surgery, but the impact of drugs on the fetus should be considered. Sulfonamide drugs should not be used in the early stages of pregnancy and the last two weeks of pregnancy.