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Fibrosarcoma

  Fibrosarcoma is a sarcoma in which the cells tend to differentiate into fibroblasts, producing reticular fibers and collagen fibers. Fibrosarcoma is relatively common in oral and maxillofacial sarcomas and is a malignant tumor derived from fibroblasts in the oral and facial area. It can occur in connective tissues within the periosteum of the jawbone, periodontal membrane, and oral soft tissues, such as the lips, cheeks, tongue, and occasionally within the jawbone. It is most common in the anterior symphysis of the mandible, the mandibular angle, and condyle, and also occurs in the posterior part of the maxilla and maxillary sinus. Fibrosarcoma within the jawbone is more common in children and young adults; fibrosarcoma of the oral soft tissues is more common in middle-aged and壮年 people, and its malignancy depends on the degree of cell differentiation and growth rate.

 

Table of contents

1. What are the causes of fibrosarcoma?
2. What complications can fibrosarcoma easily lead to?
3. What are the typical symptoms of fibrosarcoma?
4. How should fibrosarcoma be prevented?
5. What laboratory tests are needed for fibrosarcoma?
6. Dietary taboos for patients with fibrosarcoma
7. Conventional methods of Western medicine for the treatment of fibrosarcoma

1. What are the causes of fibrosarcoma?

  Fibrosarcoma can occur in injury or burn scars, osteomyelitis fistula and sinus tract, and after radiation therapy (at least 3 years after radiation therapy). Patients may experience local pain and swelling, or be accompanied by local skin redness, heat, joint effusion, and pain and limited movement of limbs or joints, etc.

 

2. What complications can fibrosarcoma easily lead to?

  Patients with fibrosarcoma may experience local pain and swelling, or be accompanied by local skin redness, heat, joint effusion, and pain and limited movement of limbs or joints, in addition to their clinical manifestations, they can also cause other diseases. Patients are prone to hematogenous metastasis and rhabdomyofibroblast hyperplasia, which should attract the high attention of clinical doctors and patients.

3. What are the typical symptoms of fibrosarcoma?

  1. Local symptoms:Local pain and swelling, or accompanied by local skin redness, heat, joint effusion, pain and limited movement of limbs or joints, etc.

  2. General symptoms:Low fever, fatigue, body discomfort, and related organ dysfunction may occur.

4. How should fibrosarcoma be prevented?

  How should fibrosarcoma be prevented?

  The prognosis of fibrosarcoma depends on its histological grade and age. The prognosis of children under 10 years old is significantly better. The recurrence rate of children and adults is roughly the same, but the metastasis is less, generally less than 10%.

5. What laboratory tests are needed for fibrosarcoma?

  X-ray findings:The main type of bone destruction, strictly speaking, there is no any tumor-like ossification. Its imaging changes are great, with no obvious characteristics. The range of bone destruction is large, with blurred boundaries, cortical bone fractures, invasion into soft tissue, and little or no bone membrane bone reaction. In some cases, fibrosarcoma can penetrate cancellous bone and cortical bone, producing a 'worm-eaten' image, with a small and fused bone destruction area.

6. Dietary taboos for patients with fibrosarcoma

  1. Diet should be high in protein and low in fat: Women with breast fibroadenoma should consume a diet high in protein and low in fat, such as dairy products, fish, beans, eggs, etc. High protein can supplement the body's amino acids, increase the patient's nutrition and resistance, and low-fat diet is to avoid excessive fat intake, which can accumulate in the breasts, increase the burden on the breasts, and worsen the condition. It is necessary to eat less greasy food, such as too much fatty meat, lard, etc.

  2. Eat more vitamin-rich foods: Patients should supplement more vitamins, and fresh fruits and vegetables are rich in vitamins, such as carrots, green vegetables, celery, apples, kiwi, coconuts, etc.

  3. It is advisable to eat lean pork, duck meat, eggs, lotus root, cabbage, tomatoes, cucumbers, eggplants, celery, tofu, apples, pears.

7. Conventional methods of Western medicine in the treatment of fibrosarcoma

  Precautions before the treatment of fibrosarcoma:

  1. Generally, surgery is mainly used, and depending on the extent of the tumor and the different clinical biological behaviors, local large block resection, segmental resection, amputation, or joint release surgery can be performed. Poorly differentiated tumors have extremely poor prognoses, as local surgical treatment cannot achieve the expected effect.

  2. Extensive resection is suitable for grade I fibrosarcoma. It can be applied to cases with selective II-IV fibrosarcoma, where the location and extent of the tumor allow for fairly extensive resection. Most cases of fibrosarcoma, especially III-IV fibrosarcoma, require amputation. Due to the fact that the tumor has expanded quite a lot on the bone during surgery (without symptoms, the timing of surgery is late), and the recurrence rate of the residual limb after surgery is high, it is necessary to carefully determine the amputation site, which can be referred to by arteriography, bone scan, CT, MRI, and the amputation site must be far from the tumor site. For example, when fibrosarcoma is located on the femur, the amputation site must be very high, and sometimes hip disarticulation or ilioabdominal disarticulation may need to be performed. The amputation site of fibrosarcoma is often higher than that of osteosarcoma.

  3. Fibrosarcoma is not sensitive to radiotherapy, and radiotherapy is only used as palliative treatment for those who cannot undergo surgery. Preoperative chemotherapy has no significant effect and is not commonly used. Periodic combined chemotherapy can be performed after surgery, and the chemotherapy regimen is the same as that for osteosarcoma, which can be tried in high-risk cases and elderly patients.

  4. Surgical resection of lung metastases is necessary and appropriate.

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