Seminal liquefaction failure

　　1. Infection factors (45%)

　　The cause of semen not liquefying is related to infection by pathogenic microorganisms. Various microorganisms such as bacteria and protozoa, if they invade the male reproductive tract, are likely to trigger a series of diseases, one of which is semen not liquefying.

　　2. Urine stimulation (30%)

　　Urine contains various acidic and alkaline chemical substances, which are easy to cause uric acid reflux into the prostate, triggering chronic prostatitis. Over time, it can also lead to semen not liquefying.

　　3. Psychological factors (25%)

　　Experts have found that 50% of patients with semen not liquefying have symptoms of anxiety, depression, and excessive tension, which are not conducive to male physical and mental health. If it persists for a long time, it can also lead to physical diseases.

　　1. Semen does not liquefy, which often affects the free movement of sperm. Under a microscope, non-liquefied semen can be seen as sperm clumping together, unable to move or only slowly wriggle. The movement of sperm in the female reproductive tract is significantly hindered by this type of semen, making it impossible for sperm to ascend into the cervical canal, uterine cavity, and fallopian tubes, thus preventing fertilization.

　　2. Common causes of seminal fluid not liquefying. From a clinical perspective, seminal fluid not liquefying is often due to insufficient fibrinolytic enzymes secreted by the prostate caused by seminal vesiculitis and prostatitis, or deficiencies of trace elements (magnesium, zinc, etc.), or congenital absence of the prostate. We know that the secretions of the prostate and seminal vesicle participate in the coagulation and liquefaction process of seminal fluid. The coagulating factor produced by the seminal vesicle causes seminal fluid to coagulate, while the proteinase, fibrinolytic protease, and other seminal fluid liquefaction factors produced by the prostate cause seminal fluid to liquefy. Once seminal vesicle or prostate inflammation occurs, it can cause obstacles in the secretion of these factors, resulting in an increase in coagulating factors or a decrease in liquefaction factors, leading to seminal fluid not liquefying. Therefore, when men have seminal fluid not liquefying, doctors often advise patients to check their prostate and other areas.

　　2. Common causes of seminal fluid not liquefying. Clinically, seminal fluid not liquefying is often caused by insufficient fibrinolytic enzymes secreted by the prostate due to seminal vesiculitis and prostatitis, or deficiencies of trace elements (magnesium, zinc, etc.), or congenital absence of the prostate. We know that the secretions of the prostate and seminal vesicle participate in the coagulation and liquefaction process of seminal fluid. The coagulating factor produced by the seminal vesicle causes seminal fluid to coagulate, while the proteinase, fibrinolytic protease, and other seminal fluid liquefaction factors produced by the prostate cause seminal fluid to liquefy. Once seminal vesicle or prostate inflammation occurs, it can cause obstacles in the secretion of these factors, resulting in an increase in coagulating factors or a decrease in liquefaction factors, leading to seminal fluid not liquefying. Therefore, when men have seminal fluid not liquefying, doctors often advise patients to check their prostate and other areas.

　　Normal semen, after being ejected from the body, becomes thick and jelly-like under the action of coagulating enzymes secreted by the seminal vesicle. It becomes more dilute 10 to >20 minutes after being ejected, due to the action of fibrinolytic enzymes secreted by the prostate gland. Liquefaction time: less than 30 minutes; Abnormal liquefaction refers to the phenomenon that semen does not completely liquefy for at least half an hour after ejaculation or starts to liquefy after more than an hour. It includes both semen not liquefying and semen liquefying slowly, and is usually referred to as semen not liquefying.

　　1. Reduced semen volume

　　Semen volume is slightly reduced, yellow and thick, with strong libido, easy to become excited and ejaculate. Common symptoms include dizziness, tinnitus, insomnia, and symptoms such as dry mouth and eyes, thin and red tongue coating.

　　2. Thick semen

　　Male semen that does not liquefy is usually thick, with a thread-like yellowish color, sometimes jelly-like, and can be in sheet-like or clumpy forms. When entering the female vagina, it may show symptoms of not liquefying for a long time, thus leading to infertility.

　　3. Pain in the vaginal and lower abdominal area

　　Patients may experience lower abdominal and vaginal pain, which can greatly disrupt their lives. Sometimes, pain can occur during ejaculation, leading to body pain and difficulty urinating. Sometimes, urination is also somewhat difficult.

　　1. Semen does not liquefy, which often affects the free movement of sperm. Under a microscope, non-liquefied semen can be seen as sperm clumping together, unable to move or only slowly wriggle. The movement of sperm in the female reproductive tract is significantly hindered by this type of semen, making it impossible for sperm to ascend into the cervical canal, uterine cavity, and fallopian tubes, thus preventing fertilization.

　　2. Common causes of seminal fluid not liquefying. From a clinical perspective, seminal fluid not liquefying is often due to insufficient fibrinolytic enzymes secreted by the prostate caused by seminal vesiculitis and prostatitis, or deficiencies of trace elements (magnesium, zinc, etc.), or congenital absence of the prostate. We know that the secretions of the prostate and seminal vesicle participate in the coagulation and liquefaction process of seminal fluid. The coagulating factor produced by the seminal vesicle causes seminal fluid to coagulate, while the proteinase, fibrinolytic protease, and other seminal fluid liquefaction factors produced by the prostate cause seminal fluid to liquefy. Once seminal vesicle or prostate inflammation occurs, it can cause obstacles in the secretion of these factors, resulting in an increase in coagulating factors or a decrease in liquefaction factors, leading to seminal fluid not liquefying. Therefore, when men have seminal fluid not liquefying, doctors often advise patients to check their prostate and other areas.

　　2. Common causes of seminal fluid not liquefying. Clinically, seminal fluid not liquefying is often caused by insufficient fibrinolytic enzymes secreted by the prostate due to seminal vesiculitis and prostatitis, or deficiencies of trace elements (magnesium, zinc, etc.), or congenital absence of the prostate. We know that the secretions of the prostate and seminal vesicle participate in the coagulation and liquefaction process of seminal fluid. The coagulating factor produced by the seminal vesicle causes seminal fluid to coagulate, while the proteinase, fibrinolytic protease, and other seminal fluid liquefaction factors produced by the prostate cause seminal fluid to liquefy. Once seminal vesicle or prostate inflammation occurs, it can cause obstacles in the secretion of these factors, resulting in an increase in coagulating factors or a decrease in liquefaction factors, leading to seminal fluid not liquefying. Therefore, when men have seminal fluid not liquefying, doctors often advise patients to check their prostate and other areas.

　　1. General examination

　　This examination mainly observes the development of male secondary sexual characteristics and should also understand the condition of male external genitalia. If the volume of the male testicles is below the normal level, it is very likely to be caused by poor testicular function, leading to seminal fluid not liquefying.

　　2. Semen analysis

　　The most important thing to do is to extract seminal fluid and undergo a comprehensive seminal fluid examination. The process mainly includes seminal fluid volume, degree of liquefaction, viscosity, sperm count, sperm viability, sperm motility, and the survival ability and color and shape of sperm. These are all indicators that can determine whether seminal fluid is in a healthy state.

　　3. Prostatic fluid examination

　　The influence of the prostate on the liquefaction of male seminal fluid is significant, so if seminal fluid does not liquefy, a prostate examination is necessary. Some proteolytic enzymes secreted by the prostate have the effect of liquefaction. If seminal fluid does not liquefy, it may indicate that the prostate has developed some serious diseases. Therefore, such an examination is relatively important.

　　4. Testicular ultrasound examination

　　The testicle is the place where sperm is produced, and the impact of testicular lesions on sperm is also significant. Ultrasound can show whether there are significant lesions in the testicle, and testicular biopsy can provide a more definite basis for judgment.

　　5. Immunological examination

　　This test can check for the presence of certain antibodies in the male body that are不利于 the normal progression of fertility.

　　Traditional Chinese medicine formula

　　1. Less abdominal blood stasis decoction

　　15 grams of cistanche deserticola, 12 grams of epimedium, 6 grams of fennel, 5 grams of dried ginger, 6 grams of cassia amara, 15 grams of rhizoma corydalis, 12 grams of myrrha, 12 grams of ligusticum chuanxiong, 10 grams of red peony root, 10 grams of pollen, 12 grams of fructus psoraleae, 12 grams of angelica sinensis. One dose per day, decocted and taken in three doses. A course of treatment is 30 days. It has the function of promoting blood circulation and removing blood stasis, invigorating the kidney and warming the yang, and is used to treat seminal liquefaction failure due to yang deficiency and cold excess.

　　2. Anticoagulant seed decoction

　　15-20 grams of rhizoma smilacis glabrae, 10-15 grams of clematis, 10-15 grams of scutellaria baicalensis, 10-15 grams of fried gardenia, 10-15 grams of alisma, 10-15 grams of plantago seed, 15-30 grams of rhizoma paridis, 15-30 grams of coix seed. A course of treatment is 30 days. One dose per day, decocted and taken in two doses. It has the function of clearing heat and promoting diuresis, and is suitable for seminal liquefaction failure due to infertility.

　　3. Liquefaction and spermatogenesis decoction

　　15 grams of salvia miltiorrhiza, 9 grams of red peony root and white peony root, 9 grams of moutan bark, 9 grams of pericarpium euphorbiae, 12 grams of raw rehmannia, 15 grams of ophiopogon, 12 grams of scrophularia, 30 grams of raw oyster shell, 12 grams of fritillaria thunbergii, 12 grams of fructus lycii, 9 grams of fructus corni, 12 grams of epimedium. Decocted and taken twice a day. A course of treatment is 15 days. It has the function of invigorating the body and nourishing yin, and is used to treat seminal liquefaction failure with low sperm count and low viability.

　　4. Liquefaction and spermatogenesis decoction

　　10 grams of basking deer antler, 6 grams of wood, 15 grams of alisma, 10 grams of plantago seed (wrapped in cloth), 12 grams of moutan bark, 15 grams of red peony root, 15 grams of salvia miltiorrhiza, 10 grams of dahurian angelica, 10 grams of anemarrhena, 10 grams of phellodendron, 5 grams of raw rehmannia, 15 grams of patrinia, 10 grams of chrysanthemum, 15 grams of poria, 15 grams of epimedium, 3 grams of licorice. Decocted and taken in two doses, one dose per day. A course of treatment is 3 weeks. This formula can clear heat and promote diuresis, nourish yin and reduce fire, and is suitable for seminal liquefaction failure due to endogenous damp-heat.

　　First, general treatment

　　1. Thoroughly treat primary diseases such as prostatitis and seminal vesiculitis, and restore their normal function.

　　2. Rinse the vagina with physiological saline containing 4% α-amylase before sexual intercourse, or inject 1 milliliter into the vagina after sexual intercourse. Alternatively, 50 milligrams of this enzyme can be mixed with cocoa butter to form a 3-centimeter-long suppository, which can be inserted into the vagina before sexual intercourse. This method was discovered because someone observed that saliva has a liquefying effect on semen and was inspired by this. α-amylase not only has a promoting effect on the liquefaction of semen, affecting vaginal or cervical secretions containing glycogen, but also can become an energy source for sperm activity. Therefore, this method is widely used.

　　3. Add normal seminal plasma to the semen to promote liquefaction. However, it is first necessary to ensure that this seminal plasma does not contain antisperm antibodies, is free from infection, and has been previously treated with high-speed centrifugation to remove precipitates and freeze-thawed three times.

　　4、将精液射入盛有培养液的容器内，用带18、19号针头的注射器反复抽吸，直至精液稀薄，再经两次离心、洗涤，最后将精子重新悬入一定量的培养液中作人工授精。

　　5、如果精液粘稠度过高，可用分段射精方法，将头三下射出的精液留在阴道内，立即抽出阴茎，将其余精液射在外面。因为后段精液主要含精囊腺分泌液，所以粘稠度较高。

　　6、3D孕育微环境疗法

　　3D强精活化疗法不光从源头解决细胞的活力。还能使使精子在能接受到的输精管、附睾等微环境一起改变。全面整体地改变精子的质量，有效解决精液不液化。

　　二、中医治疗

　　1、肾阳不足，精液寒凝

　　临床表现：精液不液化，或化而不全，内有凝块或胶冻样块；阴囊及睾丸发凉或冷感；腰膝酸软，畏寒肢冷。舌质淡苔薄白，脉沉迟或沉弦或细弱。

　　治法：补肾壮阳散寒，温化精液。

　　2、肾阳亏耗，虚火炼精

　　临床表现：精液不液化，精液量稍少，色黄而稠；性欲旺盛，易兴易泄；头晕耳鸣，失眠健忘；口干目涩。舌红苔薄黄或少苔，脉细数。

　　治法：滋阴清热，液化精液。

　　3、湿热内蕴，熏灼精液

　　临床表现：精液不液化，粘稠色黄，尿道灼热，或会阴部胀痛不适，或射精疼痛。周身困倦；小便热赤，或尿后有白浊。舌红苔黄腻，脉濡数或滑数。

　　治法：清热利湿，滋阴降火。

　　4、脾肾阳虚，痰湿内结

　　临床表现：精液不液化，量多浊稠；形体肥胖，肢体困重不温；喉中痰多。舌淡苔白腻，脉沉滑。

　　治法：温补脾肾，化痰除湿。

　　5、血瘀清淤，稠厚不化

　　临床表现：精液不液化，小腹及会阴部有固定性疼痛或隐痛；肝肿大或脾肿大。舌质紫暗，或有瘀点或瘀斑，脉涩。

　　治法：活血化瘀，升化精液。

　　6、中成药：李氏灵坤膏，采用综合疗法，具有不错的康复疗效。