Cholestatic syndrome

　　Various neonatal hemolytic diseases can cause this disease. Due to excessive hemolysis, the bilirubin in bile increases, causing the concentration of bile to rise, followed by bile concentration, forming bile plugs (bileplug). These bile plugs accumulate together to form bile plugs, causing obstructive jaundice. In addition, high concentrations of bilirubin can also cause liver cell swelling, leading to secondary intrahepatic bile stasis, which is different in nature from extrahepatic obstruction caused by cholelithiasis.

　　Easier to develop intrahepatic bile stasis, neonatal hemolytic disease and other diseases. Intrahepatic bile stasis is a serious cholestasis liver disease in infants and young children, often due to unclear causes, modern medicine lacks effective treatment, half of the children can develop into liver cirrhosis, and most die from liver failure between the ages of 2 to 15. Severe liver function damage, especially when direct bilirubin is higher than indirect bilirubin, the total bile acid is significantly increased.

　　1. Hemolytic symptoms:Anemia usually worsens gradually within 1-2 weeks after birth, is not proportional to the degree of jaundice, with liver and spleen enlargement, increased reticulocytes, and some patients have a positive Coombs test or Rh factor incompatibility between mother and child.

　　2. Obstructive jaundice:Generally appears 2 days after birth, lasts for 3 weeks, with varying degrees of severity, obstructive; feces clay-colored.

　　This disease is mainly caused by Rh incompatibility or AB blood type or other blood type incompatibility, so proactive premarital and prenatal examinations should be carried out. The diet should be light, and low-fat high-protein diet should be consumed, as high-fat foods can stimulate gallbladder contraction and cause abdominal pain. Consume more high-fiber foods such as vegetables, fruits, and whole grains. Limit the intake of cholesterol. Absolutely do not eat foods rich in cholesterol such as internal organs and egg yolks. Supplement more vitamin K, such as spinach and broccoli, which are rich in content. Avoid foods that produce gas, such as potatoes, sweet potatoes, legumes, onions, radishes, carbonated drinks, and acidic fruit juices, coffee, cocoa, and so on.

　　The anemia of concentrated bile syndrome usually worsens gradually within 1-2 weeks after birth, is not proportional to the degree of jaundice, with liver and spleen enlargement, increased reticulocytes, positive urine bilirubin, negative urine urobilinogen, and increased serum bilirubin concentration, mainly conjugated bilirubin.

　　Dietary注意事项 for concentrated bile syndrome:

      1. What foods are good for the body with concentrated bile syndrome?

　　Eat light and balanced nutrition.

　　2. What foods should be avoided for concentrated bile syndrome?

　　Avoid spicy and stimulating foods.

　　Blood exchange therapy, ultraviolet light therapy, and other methods can be used to prevent the occurrence of kernicterus. Those with liver function damage should receive liver protection treatment. Modern pharmacological research has confirmed that ginseng, astragalus, aconite, atractylodes, and other herbs can improve the phagocytic function of the reticuloendothelial system, increase the serum complement and immunoglobulin content, promote the conversion rate of lymphocytes and the formation rate of rosette formation, promote the activity of natural killer cells, induce interferon and interleukin.