Hand-Foot Syndrome

       Hand and foot syndrome is a sensory atrophy of the palm-sole or limb erythema caused by chemotherapy, which is a skin toxicity, mainly occurring in the compressed area. It may occur during the process of chemotherapy or molecular targeted therapy in tumor patients..

Due to the possibility of skin swelling or erythema, desquamation, fissures, nodular blisters, or severe pain, it may lead to local infection in patients, resulting in other related diseases..

        Typical symptoms include numbness, hypoesthesia, paresthesia, tingling, painless or painful sensation, swelling or erythema of the skin, desquamation, fissures, nodular blisters, or severe pain, etc.

Avoid friction and contact with high-temperature items on the hands and feet in daily life as much as possible, such as not wearing tight and uncomfortable shoes, avoiding friction and pressure on the hands and feet, avoiding intense exercise and physical labor, reducing the number of times the hands and feet come into contact with hot water, including dishwashing and hot baths, and wearing dishwashing gloves does not reduce the injury because rubber can store heat and damage the skin of the palms..

　　Severe discomfort such as moist desquamation, ulcers, blisters, or severe pain and/or inability to work or carry out daily activities due to hand and/or foot wet desquamation, ulcers, blisters, or severe pain. The pain is intense, the skin function is lost, and it is relatively rare.

      Avoid eating spicy and irritating foods.

Common adverse reactions of molecular targeted drugs for VEGF, such as sunitinib, sorafenib, etc. HFSR usually occurs in the early stage of treatment, generally the most severe after 2 weeks of medication, and then gradually subsides. The pain usually significantly reduces or even disappears by the 6th to 7th week of treatment. With the extension of treatment time, the incidence of HFSR also decreases. The phase III clinical trial results show that the incidence of HFSR for sunitinib and sorafenib is 20% and 30% respectively.