1. Pre-congestion phase:It can occur shortly after exposure to a damp and cold environment, lasting for several hours to several days. Initially, there is only a local sensation of cold discomfort, which gradually becomes numb, the limb becomes cold and pale, numbness, mild swelling, and the pulse around the limb weakens or disappears with prolonged exposure.
2. Congestion phase:The onset usually occurs several hours after the patient leaves a damp and cold environment, lasting for 6 to 10 weeks. The affected limb becomes red, hot, without sweating, and shows obvious swelling, with a pronounced pulse. Diffuse burning pain appears, which intensifies continuously, and is replaced by paroxysmal sharp pain around ten days later. The pain worsens with heat and relieves with cold, and can be induced by various stimuli. Symptoms may include mild tachycardia, low fever, transient proteinuria, and systemic symptoms. In severe cases, blisters, blood blisters, intradermal or subcutaneous hemorrhage, skin desquamation, superficial gangrene, hair and nail plate loss, and often accompanied by bacterial infection.
3. Congestion stage:It can last for several months or years, with local temperature reduction of the affected limb, a sense of coldness, common Raynaud's phenomenon, hyperesthesia, sweating, joint stiffness, recurrent edema, bullae, atrophy of the skin and its appendages, and other phenomena.